RECK, MMP-9及TGF-β1在胃癌组织中的表达及其相互关系
胃癌;RECK蛋白;基质金属蛋白酶-9;转化生长因子-β1;免疫组织化学,RECK,MMP-9及TGF-β1在胃癌组织中的表达及其相互关系,宋国庆,王强,宋国庆,通讯作者:,Expressionofreversion-inducing-cysteine-richproteinwithKaza
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宋国庆, 王强, 中国医科大学附属盛京医院胃肠外科 辽宁省沈阳市 110004
宋国庆, 2004年中国医科大学附属盛京医院普通外科硕士生, 主要从事胃肠肿瘤的临床研究.
通讯作者: 王强, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学附属盛京医院胃肠外科. wangq@cmu2h.com
电话: 024-83955060
收稿日期: 2007-03-03 接受日期: 2007-04-02
Expression of reversion-inducing-cysteine-rich protein with Kazal motifs, matrix metalloproteinase-9 and transforming growth factor-β1 and their correlations in gastric carcinomas
Guo-Qing Song, Qiang Wang
Guo-Qing Song, Qiang Wang,Department of Gastroduodenal Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to:Dr. Qiang Wang, Department of Gastroduodenal Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. wangq@cmu2h.com
Received:2007-03-03 Accepted:2007-04-02
Abstract
AIM: To study the expression of RECK (reversion-inducing-cysteine-rich protein with Kazal motifs), MMP-9 (matrix metalloproteinase-9), and TGF-β1 (transforming growth factor-β1) as well as their correlations in gastric cancer, and to investigate their roles in the carcinogenesis and and development.
METHODS: PV-9000 immunohistochemistry was used to measure the expression of RECK, MMP-9, and TGF-β1 in 54 samples of gastric carcinoma selected from paraffin wax-embodied specimens with complete clinicopathological data, and another 15 cases of normal gastric mucosa.
RESULTS: The expression rate of RECK in gastric cancer was low (51.9%), and reduced with the increased invasive depth and clinical stages, decreased histological differentiation and occurrence of lymphatic and long-distance metastasis (P < 0.05). The expression rate of MMP-9 in gastric cancer was high (75.9%), and elevated with the increased invasive depth and clinical stages, decreased histological differentiation, and occurrence of lymphatic metastasis (P < 0 ......
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