乙肝病毒基因型与肝脏病理改变的关系
乙型肝炎病毒;慢性乙型肝炎;基因型;病理学;巢氏聚合酶链式反应;荧光定量聚合酶链式反应,钟崇芳,郝娃,李卓,孟欣,严艳,牛京勤,殷继明,通讯作者:,RelationshipbetweenthehistologyandgenotypeofhepatitisBvir
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钟崇芳, 郝娃, 李卓, 孟欣, 严艳, 牛京勤, 殷继明, 首都医科大学附属北京佑安医院北京市卫生局肝炎研究所 北京市 100069
北京市科委重大基金项目, No. H020920020590
通讯作者: 李卓, 100069, 北京市, 首都医科大学附属北京佑安医院北京市卫生局肝炎研究所. lizhuo_youan@163.com
电话: 010-83997427
收稿日期: 2007-03-12 接受日期: 2007-04-02
Relationship between the histology and genotype of hepatitis B virus DNA in chronic hepatitis B patients Chong-Fang Zhong, Wa Hao, Zhuo Li, Xin Meng, Yan Yan, Jing-Qin Niu, Ji-Ming Yin
Chong-Fang Zhong, Wa Hao, Zhuo Li, Xin Meng, Yan Yan, Jing-Qin Niu, Ji-Ming Yin, Hepatitis Institute of Beijing Health Bureau, Beijing You’an Hospital Affiliated to Capital University of Medical Sciences, Beijing 100069, China
Supported by Major Project Fund of Beijing Science and Technology, No. H020920020590
Correspondence to: Zhuo Li, Hepatitis Institute of Beijing Health Bureau, Beijing You’an Hospital Affiliated to Capital University of Medical Sciences, Beijing 100069, China. lizhuo_youan@163.com
Received: 2007-03-12 Accepted: 2007-04-02
Abstract
AIM: To investigate the relationship between hepatitis B virus DNA genotype and pathological changes in patients with chronic hepatitis B.
METHODS: A total of 92 chronic hepatitis B (CHB) patients were tested for HBV genotype and sub-genotypes by nested and fluorescence quantitative polymerase chain reactions, respectively. Liver biopsy specimens of all patients were taken and histological activity index (HAI) necroinflammation (HAI-NI), and fibrosis (HAI-F) scores were calculated.
RESULTS: Among the 92 cases, 17 (18.48%) had genotype B (sub-genotype B2), 17 (18.48%) had mixed B/C genotype (sub-genotype B2/Ca) and 58 (63.04%) had C (sub-genotype Ca) infections. In the 17 CHB patients with genotype B, HAI-NI were 35.29%, 58.82% and 5.88% for G1, G2 and G3, respectively, HAI-F scores were 58.82%, 29.41% and 11.76% for S1, S2, and S3, respectively; In the 17 cases with mixed B/C genotype infection, HAI-NI were 35 ......
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