凝结芽孢杆菌活菌TBC169株对右旋葡聚糖硫酸钠引发大鼠溃疡性结肠炎的治疗作用
凝结芽胞杆菌;右旋葡聚糖硫酸钠;大鼠;溃疡性结肠炎;肠道菌群,万阜昌,崔云龙,闫述翠,通讯作者:,TherapeuticeffectsofBacilluscoagulansonthedextransodiumsulf
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万阜昌, 北京天施康医药科技发展有限公司医学部 北京市100037
崔云龙, 闫述翠, 青岛东海药业有限公司菌种鉴定部 青岛市 266400
万阜昌, 1964年江西医学院毕业, 研究员, 主要从事药理学研究工作.
国家科技部863计划项目, No.2003AA2ZC50
通讯作者: 万阜昌, 100037, 北京市海淀区阜成路白堆子, 北京天施康医药科技发展有限公司医学部. wanfc2@126.com
电话: 010-68438088 传真: 010-68438088
收稿日期: 2007-02-26 接受日期: 2007-03-31
Therapeutic effects of Bacillus coagulans on the dextran sodium sulfate-induced ulcerative colitis in ratsFu-Chang Wan, Yun-Long Cui, Shu-Cui Yan
Fu-Chang Wan, Department of Medicine, Beijing Tian Shi Kang Medicine and Technology Corporation Limited, Beijing 100037, China
Yun-Long Cui, Shu-Cui Yan, Division of Bacterial Strain Selection and Identification, Qingdao Eastern Sea Pharmaceutical Corporation Limited, Qingdao 266400, Shangdong Province, China
Supported by The National “863” Plan Item from the Ministry of Science and Technology, China, No.2003AA2ZC50
Correspondence to: Fu-Chang Wan, Department of Medicine, Beijing Tian Shi Kang Medicine and Technology Corporation Limited, Beijing 100037, China. wanfc2@126.com
Received: 2007-02-26 Accepted: 2007-03-31
Abstract
AIM: To investigate the effect of Bacillus coagulans (BC, TBC169 strain) in the treatment of rats with ulcerative colitis induced by dextran sodium sulfate (DSS).
METHODS: DSS was used to induce UC in Sprague Dawley rats, and then the rats were treated with 107 CFU/mL, 106 CFU/mL BC, 0.02 g/mL sulfasalazine and normal saline (control), respectively. After 21 days of treatment, the body weight, colorectal wet weight, intestinal mucosal ulcer, erosion spots and area, myeloperoxidase (MPO) activity, and intestinal bacterial flora were observed.
RESULTS: After treatment, the body weights of rats in all the groups were increased, especially in the group received BC at 107 CFU/mL (P < 0.05). Intestinal wet weight, ulcerative number and area, and MPO activity were significantly reduced in all the treatment groups (P < 0 ......
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