钙池操纵的Ca2+通道的激活机制研究进展
钙池操纵的Ca2+通道;钙内流因子模型;构象耦联模型,钙池操纵的Ca2+通道的激活机制研究进展,张子超,张宗明,通讯作者:,Advancesinunderstandingtheactivationmechanismofstore-operatedCa2+channels,Zi-ChaoZha
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张子超, 同济大学附属同济医院普外一科 上海市 200065
张宗明, 清华大学第一附属医院消化中心普外科 北京市 100016
张宗明, 教授, 博士生导师, 主要从事普通外科临床和基础研究.
国家自然科学基金资助项目, No. 30270532和No. 30670774
教育部“跨世纪优秀人才培养计划”基金资助项目, 教技函No. 2002-48
清华-裕元医学科学研究基金资助项目, No. 20240000531
通讯作者: 张宗明, 100016, 北京市朝阳区酒仙桥一街坊6号, 清华大学第一附属医院消化中心普外科. zhangzongming@mail.tsinghua.edu.cn
电话: 010-64372362 传真: 010-64361322
收稿日期: 2007-03-13 接受日期: 2007-03-31
Advances in understanding the activation mechanism of store-operated Ca2+ channels
Zi-Chao Zhang, Zong-Ming Zhang
Zi-Chao Zhang, the First Department of General Surgery, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China
Zong-Ming Zhang, Department of General Surgery, Digestive Medical Center, the First Affiliated Hospital of Tsinghua University, Beijing 100016, China
Supported by: the National Natural Science Foundation of China, No. 30270532, 30670774; Trans-Century Training Programme Foundation for the Talents by the Ministry of Education of China, Official Letter No. 2002-48; and Tsinghua-Yue-Yuan Medical Science Fund, No. 20240000531
Correspondence to: Professor Zong-Ming Zhang, Department of General Surgery, Digestive Medical Center, the First Affiliated Hospital of Tsinghua University, Beijing 100016, China. zhangzongming@mail.tsinghua.edu.cn
Received: 2007-03-13 Accepted: 2007-03-31
Abstract
As one of the major Ca2+ channels for Ca2+ influx in non-excitable cells, the store-operated Ca2+ channel (SOC) is involved in a variety of pathological and physiological processes. The SOC has received much scientific attention regarding sub-types of the receptor-activated Ca2+ channel. The activation mechanisms of SOCs have always been an important focus of research on Ca2+ signal pathways. However, a generally accepted theory has yet to be established ......
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