结肠癌及癌前病变组织中COX-2及VEGF的表达
结肠癌;癌前病变;环氧合酶-2;血管内皮生长因子,陈建华,通讯作者:,ExpressionofCyclooxygenase-2andVascularendothelialgrowthfactorinprecancerouslesionsandcol
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陈建华, 驻马店市中心人民医院普外科, 河南省驻马店市, 463000
通讯作者: 陈建华, 463000, 河南省驻马店市中华路西段779号, 驻马店市中心人民医院普外科. cjh@126.com
电话: 0396-2926218
收稿日期: 2007-04-27 接受日期: 2007-05-11
Expression of Cyclooxygenase-2 and Vascular endothelial growth factor in precancerous lesions and colon carcinoma tissue
Jian-Hua Chen
Jian-Hua Chen, Department of General Surgery, Zhumadian Central People's Hospital, Zhumadian 463000, Henan Province, China
Correspondence to: Jian-Hua Chen, Department of General Surgery, Zhumadian Central People's Hospital, 779 Zhonghua Road, Zhumadian 450052, Henan Province, China. cjh@126.com
Received: 2007-04-27 Accepted: 2007-05-11
Abstract
AIM: To determine the clinical significance of expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in normal colon epithelium near colon carcinoma, and in precursors and colon carcinoma.
METHODS: Immunohistochemistry (ABC) was utilized to detect the expression of COX-2 and VEGF in 40 normal colon epithelium, 27 adenomatous polyposis of the colon, and 40 colon carcinoma tissues.
RESULTS: Immunoreactivity of COX-2 and VEGF in adenomatous polyposis of the colon and colon carcinoma was much higher than that in normal tissues (COX-2, 63.0 and 77.5% vs 0.0 and 0.0%; VEGF, 70.4 and 80.0% vs 25.0 and 25.0%, respectively; P < 0.05). The relationship between COX-2 and VEGF was statistically significant (r = 0.411, P < 0.05).
CONCLUSION: COX-2 and VEGF expression is up-regulated in adenomatous polyposis of the colon and colon carcinoma ......
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