北京地区乙肝病毒S基因序列多态性及其分布
乙型肝炎病毒;S基因;多态性;基因型;血清型;聚合酶链反应,王继荣,赵洪斌,季芬,曾长青,周莉,王继荣,通讯作者:,SequencepolymorphisminthesurfacegeneofhepatitisBvirusanditsdist
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王继荣, 赵洪斌, 季芬, 中国科学院北京基因组研究所 北京市 101300; 中国科学院研究生院 北京市 100049
曾长青, 中国科学院北京基因组研究所 北京市 101300
周莉, 丁惠国, 首都医科大学附属北京佑安医院消化科 北京市 100069
王继荣, 2005年内蒙古大学生命科学学院毕业, 2005至今中国科学院研究生院硕士研究生, 主要从事乙型肝炎病毒基因组突变及其临床关系研究.
中国科学院知识创新工程重大项目, No. KSCX2-SW-207
北京市教育委员会基金项目, No. KM20070025024
通讯作者: 曾长青, 101300, 北京市北京顺义空港工业区B区6号楼, 中国科学院北京基因组研究所. czeng@genomics.org.cn
电话: 010-80481146 传真: 010-80498676
收稿日期: 2007-07-12 修回日期: 2007-08-12
Sequence polymorphism in the surface gene of hepatitis B virus and its distribution in the Beijing area
Ji-Rong Wang, Li Zhou, Hong-Bin Zhao, Fen Ji, Hui-Guo Ding, Chang-Qing Zeng
Ji-Rong Wang, Hong-Bin Zhao, Fen Ji,Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300, China; Graduate University of Chinese Academy of Sciences, Beijing 100049, China
Chang-Qing Zeng,Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300, China
Li Zhou, Hui-Guo Ding,Department of Digestive Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Supported by:the Knowledge Innovation Program (KIP), Important Project of the Chinese Academy of Sciences, No. KSCX2-SW-207 and the Foundation of Beijing Municipal Education Commission, No. KM20070025024
Correspondence to:Chang-Qing Zeng, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing Airport Industrial Zone B-6, Shunyi, Beijing 101300, China. czeng@genomics.org.cn
Received:2007-07-12 Revised:2007-08-12
Abstract
AIM: To investigate the sequence polymorphism of the surface (S) gene of hepatitis B virus (HBV), to study the distribution of viral genotypes/serum subtypes circulating in the Beijing area, and to search for possible correlations between viral genotypes/serum subtypes and clinical conditions.
METHODS: HBV DNA samples from 69 patients from the Beijing area were isolated and purified ......
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