冬凌草单药及与化疗合用治疗食管癌205例
冬凌草;化疗;食管癌;临床疗效,樊青霞,王瑞,王瑞林,樊青霞,通讯作者:,ClinicalefficacyoftreatmentbyRabdosiarubescensaloneorincombinationchemotherapyforesophag
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樊青霞, 王瑞, 王瑞林, 郑州大学第一附属医院肿瘤科 河南省郑州市 450052
樊青霞, 博士生导师, 主要从事恶性肿瘤的临床研究.
通讯作者: 王瑞林, 450052, 河南省郑州市建设东路1号, 郑州大学第一附属医院肿瘤科. wangruihello@yahoo.com.cn
电话: 0371-65165762
收稿日期: 2007-02-14 修回日期: 2007-08-07
Clinical efficacy of treatment by Rabdosia rubescens alone or in combination chemotherapy for esophageal cancer
Qing-Xia Fan, Rui Wang, Rui-Lin Wang
Qing-Xia Fan, Rui Wang, Rui-Lin Wang,Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Correspondence to:Rui-Lin Wang, Department of Oncology, the First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou 450052, Henan Province, China. wangruihello@yahoo.com.cn
Received:2007-02-14 Revised:2007-08-07
Abstract
AIM: To observe the clinical efficacy of Rabdosia rubescens alone or in combination chemotherapy for the treatment of esophageal cancer patients.
METHODS: We enrolled 448 patients diagnosed with esophageal cancer by pathology and X-ray; 76 in the early stage were treated withRabdosia rubescens alone; 372 were in the middle to late stage and among these, 167 were treated with Rabdosia rubescens alone, while 205 were treated with Rabdosia rubescens plus chemotherapy.
RESULTS: For early-stage esophageal cancer patients treated withRabdosia, survival rates at 3, 5, 10 and 13 years were significantly higher than those for patients without treatment (98.68%vs 51.52%, 84.02% vs 28.62%, 63.49% vs 11.45%, 50.13% vs 8.59%; P < 0.001). For late-stage esophageal cancer, the response rate to Rabdosia rubescens plus chemotherapy was significantly higher than that in PYM-BLM based chemotherapy alone (66.82% vs 42.85%, P < 0.01). There was no significant difference regarding side effects between Rabdosia rubescens plus chemotherapy and chemotherapy alone (P > 0.05).
CONCLUSION: For early-stage esophageal cancer, Rabdosia rubescens appears to control disease and prolong survival time ......
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