肝内肌成纤维细胞和星状细胞在肝纤维化中的作用
肌成纤维细胞;肝星状细胞;肝纤维化,李定国,汪保灿,李定国,通讯作者:,Functionsofmyofibroblastsandhepaticsatellitecellsinliverfibrosis,Ding-GuoLi,Bao-CanWa
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李定国, 汪保灿, 上海交通大学医学院附属新华医院消化内科 上海市 200092
李定国, 教授, 主任医师, 博士生导师, 主要从事肝纤维化的防治研究.
通讯作者: 李定国, 200092, 上海市, 上海交通大学医学院附属新华医院消化内科. dingguo_li@263.net
电话: 021-65790000-3361 传真: 021-55571294
收稿日期: 2007-06-11 修回日期: 2007-08-13
Functions of myofibroblasts and hepatic satellite cells in liver fibrosis
Ding-Guo Li, Bao-Can Wang
Ding-Guo Li, Bao-Can Wang,Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China
Correspondence to:Ding-Guo Li, Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China. dingguo_li@263.net
Received:2007-06-11 Revised:2007-08-13
Abstract
Liver fibrosis represents wound-healing responses from liver tissue injury. Multiple mechanisms underlying liver fibrogenesis have been explored. Inflammatory cytokines stimulate fibrogenetic cell proliferation and activation, the production of extracellular matrix (ECM), and the secretion of various cytokines and enzymes. All such alterations lead to a relative increase in the deposition of ECM components. Decreased degradation occurs with resulting excessive ECM accumulation in the liver. It has recently been suggested that, besides hepatic stellate cells, myofibroblasts may also constitute an important population of matrix-producing cells in liver fibrosis, and especially in cholestatic fibrosis. Confirmation of such observations will be required for the development of antifibrotic strategies that specifically and efficiently target cells responsible for the different types of liver fibrosis.
Key Words: Myofibroblast; Hepatic satellite cell; Liver fibrosis
Li DG, Wang BC. Functions of myofibroblasts and hepatic satellite cells in liver fibrosis. Shijie Huaren Xiaohua Zazhi 2007; 15(23): 2473-2476
摘要
肝纤维化是不同病因长期作用于肝脏所致损伤后修复反应, 发病机制主要是肝内纤维生成, 细胞活化、增殖, 合成大量细胞外基质(extracellur matrix, ECM), 并伴有ECM降解不足, 最终导致其在肝内大量积聚 ......
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