肝星状细胞中的TGFβ信号转导通路
肝星状细胞;转化生长因子β;信号转导通路,李丽,王宝恩,通讯作者:,Transforminggrowthfactorβsignalinginhepaticstellatecells,LiLi,Bao-EnWang,Correspondenceto:
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李丽, 王宝恩, 首都医科大学附属北京友谊医院肝病中心 北京市 100050
通讯作者: 李丽, 100050, 北京市, 首都医科大学附属北京友谊医院肝病中心. lili519_72@126.com
电话: 010-63138028
收稿日期: 2007-04-19 修回日期: 2007-08-10
Transforming growth factor β signaling in hepatic stellate cells
Li Li, Bao-En Wang
Li Li, Bao-En Wang,Liver Disease Center, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China
Correspondence to:Li Li, Liver Disease Center, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China. lili519_72@126.com
Received:2007-04-19 Revised:2007-08-10
Abstract
The activation of hepatic stellate cells (HSCs) plays a central role in liver fibrogenesis. Transforming growth factor β (TGFβ) initiates the activation of HSCs. In HSCs, TGFβ signaling is mainly transduced through the ALK5/smad2/3 pathway. However, recent evidence has shown that the ALK1/smad1/5 pathway and non-Smad signaling also play important roles in the activation of HSCs. For determining an effective anti-TGFβ strategy for liver fibrosis, it is necessary to investigate the complex signaling of TGFβ in HSCs.
Key Words: Hepatic stellate cells; Transforming growth factor β; Signal transduction pathway
Li L, Wang BE. Transforming growth factor β signaling in hepatic stellate cells. Shijie Huaren Xiaohua Zazhi 2007; 15(23): 2516-2520
摘要
肝星状细胞(hepatic stellate cell, HSC)活化是肝纤维化形成的中心环节, 转化生长因子β(transforming growth factor β, TGFβ)启动了肝星状细胞的活化, TGFβ信号在HSC内主要通过ALK5/smad2/3途径在HSC内传递, 而近年来的研究表明, ALK1/smad1/5途径及非smad信号也起非常重要的作用. 有必要对HSC中复杂的TGFβ信号进行研究, 为有效抗TGFβ治疗肝纤维化提供依据.
关键词: 肝星状细胞; 转化生长因子β; 信号转导通路
李丽, 王宝恩. 肝星状细胞中的TGFβ信号转导通路. 世界华人消化杂志 2007;15(23):2516-2520
0 引言
HSC活化并分泌大量细胞外基质, 是肝纤维化形成的中心环节. TGFβ因启动、促进HSC活化而在肝纤维化形成过程中起重要作用. HSC中TGFβ信号主要通过ALK5/smad2/3途径传递, 而近年来的研究表明, ALK1/smad1/5途径及非smad信号也起非常重要的作用[1-2] ......
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