贲门癌组织环氧化酶-2和血管生成因子的表达及其与血管生成的关系
环氧化酶-2;血管生成因子;贲门肿瘤;血管生成;微血管密度;免疫组织化学,产松苗,欧希龙,陈国胜,颜芳,孙为豪,通讯作者:,Expressionofcyclooxygenase-2andvascularendothelialgro
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产松苗, 上海梅山医院消化科 江苏省南京市 210039
欧希龙, 陈国胜, 颜芳, 东南大学临床医学院附属中大医院消化科 江苏省南京市 210009
孙为豪, 南京医科大学第一附属医院老年医学科 江苏省南京市 210029
产松苗, 医学硕士, 主要从事消化系肿瘤的血管形成及其干预机制方面的研究.
通讯作者: 欧希龙, 210009, 江苏省南京市, 东南大学临床医学院附属中大医院消化科. ouxilong@126.com
收稿日期: 2007-08-20 修回日期: 2007-10-03
Expression of cyclooxygenase-2 and vascular endothelial growth factor in carcinoma of the gastric cardia and its correlation with angiogenesis
Song-Miao Chan, Xi-Long Ou, Wei-Hao Sun, Guo-Sheng Chen, Fang Yan
Song-Miao Chan, Department of Gastroenterology, the Shanghai Meishan Hospital, Nanjing 210039, Jiangsu Pro-vince, China
Xi-Long Ou, Guo-Sheng Chen, Fang Yan, Department of Gastroenterology, the Affiliated Zhongda Hospital of Clinical Medical College of Southeast University, Nanjing 210009, Jiangsu Province, China
Wei-Hao Sun, Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Correspondence to: Xi-Long Ou, Department of Gastro-enterology, the Affiliated Zhongda Hospital of Clinical Medical College of Southeast University, Nanjing 210009, Jiangsu Province, China. ouxilong@126.com
Received: 2007-08-20 Revised: 2007-10-03
Abstract
AIM: To investigate the expression of cycloo-xygenase (COX)-2 and vascular endothelial growth factor (VEGF) in carcinoma of the gastric cardia, and to evaluate the relationship between COX-2, VEGF expression and angiogenesis, and clinicopathological features of carcinoma of the gastric cardia.
METHODS: Forty-six resected tumor specimens were obtained from patients with carcinoma of the gastric cardia, and 21 corresponding paracancerous normal tissues were randomly selected as a control group. Immunohistochemical staining was used for detecting the expression of COX-2 and VEGF. Monoclonal antibody against CD34 was used for visualizing vascular endothelial cells, and microvascular density (MVD) was determined by counting the number of CD34-positive vascular endothelial cells ......
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