肝细胞癌组织SOCS1和STAT3蛋白的表达意义
肝细胞癌;细胞因子信号转导抑制因子1;信号转导子与转录激活子家族3;免疫组化,张荣贵,臧国庆,汤正好,冯洁,余永胜,通讯作者:,ExpressionofSOCS1andSTAT3inhepatocellularcarcinomatissuesan
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张荣贵, 苏州大学05级消化病学硕士生 江苏省苏州市 215213
臧国庆, 汤正好, 冯洁, 余永胜, 上海市第六人民医院感染科 上海市 200233
张荣贵, 苏州大学消化病学硕士生, 主治医师, 主要从事消化系肿瘤的基础研究和临床诊治.
通讯作者: 余永胜, 200233, 上海市宜山路600号, 上海市第六人民医院感染科. yuyongsheng@medmail.com.cn
电话: 021-64030482
收稿日期: 2007-05-18 修回日期: 2007-10-10
Expression of SOCS1 and STAT3 in hepatocellular carcinoma tissues and its significance
Rong-Gui Zhang, Guo-Qing Zang, Zheng-Hao Tang, Jie Feng, Yong-Sheng Yu
Rong-Gui Zhang, Graduate Student of Digestive Medicine in Suzhou University, Suzhou 215213, Jiangsu Province, China
Guo-Qing Zang, Zheng-Hao Tang, Jie Feng, Yong-Sheng Yu, Department of Infectious Diseases, the Sixth Peoples’ Hospital, Shanghai 200233, China
Correspondence to: Yong-Sheng Yu, Department of Infectious Diseases, the Sixth Peoples’ Hospital, 600 Yishan Road, Shanghai 200233, China. yuyongsheng@medmail.com.cn
Received: 2007-05-18 Revised: 2007-10-10
Abstract
AIM: To investigate the expression of SOCS1 and STAT3 in hepatocellular carcinoma (HCC), as well as their significance in the occurrence and development of HCC.
METHODS: The expression of SOCS1and STAT3 proteins were examined by immunohistochemistry in 48 tissue specimens from HCC and their para-carcinoma tissues, 11 from liver cirrhosis tissues, and 11 from normal liver tissues.
RESULTS: The positive rate of SOCS1 expression was significantly higher in the para-carcinoma tissues than in the HCC tissues (P < 0.001), but its expression in liver cirrhosis and normal liver tissues was negative. While the positive rate of STAT3 expression was markedly higher in HCC than in para-carcinoma tissues (P < 0.001), its expression in the latter was higher than that in liver cirrhosis and normal liver tissues (P < 0.001). Expression of SOCS1 was significantly correlated with tumor size (P < 0.01). Expression of STAT3 was correlated with the expression of alpha fetoprotein (AFP) in HCC tissues (P < 0 ......
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