中药降脂颗粒对非酒精性脂肪肝大鼠肝脏瘦素受体mRNA及P-JAK2/P-STAT3的影响
降脂颗粒;东宝甘泰;非酒精性脂肪肝;Leptin;瘦素受体mRNA;P-JAK2;P-STAT3,马赞颂,柳涛,郑培永,邢练军,季光,马赞颂,通讯作者:,EffectofJiangzhigranuleson
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马赞颂, 柳涛, 郑培永, 邢练军, 季光, 上海中医药大学附属龙华医院消化内科 上海中医药大学脾胃病研究所 上海市 200032
马赞颂, 上海中医药大学2004级医学硕士, 从事中医药防治慢性肝病的研究.
教育部新世纪优秀人才支持计划, 上海市中药现代化专项资助项目, No. 05DZ19702-4
国家自然科学基金资助项目, No. 30772802
通讯作者: 季光, 200032, 上海市宛平南路725号, 上海中医药大学附属龙华医院消化内科, 上海中医药大学脾胃病研究所. jiliver@vip.sina.com
电话: 021-64868999 传真: 021-64286261
收稿日期: 2007-07-13 修回日期: 2007-10-23
Effect of Jiangzhi granules on expression of leptin receptor mRNA, P-JAK2 and P-STAT3 in rats with non-alcoholic fatty liver disease
Zan-Song Ma, Tao Liu, Pei-Yong Zheng, Lian-Jun Xing, Guang Ji
Zan-Song Ma, Tao Liu, Pei-Yong Zheng, Lian-Jun Xing, Guang Ji, Department of Gastroenterology, Institute of Spleen and Stomach Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Supported by: Shanghai Chinese Medicine Modernization Special Purpose Program, Supporting Project for Elitists in New Century of the Ministry of Education, No. 05DZ19702-4; National Natural Science Foundation of China, No. 30772802
Correspondence to: Dr. Guang Ji, Department of Gastroenterology, Institute of Spleen and Stomach Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai 200032, China. jiliver@vip.sina.com
Received: 2007-07-13 Revised: 2007-10-23
Abstract
AIM: To study the effect of Jiangzhi granules on non-alcoholic fatty liver disease in rats, and on the expression of leptin receptor mRNA, P-JAK2 and P-STAT3 in the liver.
METHODS: Sixty-eight male Sprague–Dawley rats were randomly divided into two groups: blank group (n = 8), fed a normal diet; Model group (n = 60), fed high fat diet, Fifty-eight rats in Model group were randomly divided into five groups: control group (n = 10), Jiangzhi granules low-dose group (n = 12), Jiangzhi granules moderate dose group (n = 12), Jiangzhi granules high-dose group (n = 12) and Dongbao Gantai (DB) group (n = 12) ......
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