肝细胞癌中金属硫蛋白表达下调及其临床病理学意义
肝细胞癌;金属硫蛋白;免疫组织化学;组织芯片,张树辉,徐爱民,通讯作者:,Down-regulatedexpressionofmetallothioneinanditsclinicopathologicalsignificanceinhepatoc
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张树辉, 上海中医药大学附属岳阳医院病理科 上海市 200437
徐爱民, 第二军医大学东方肝胆外科医院 上海市 200438
张树辉, 博士后, 副主任医师, 副教授, 主要从事肝脏肿瘤临床病理诊断和分子病理学研究.
上海市教育委员会研究基金资助项目, No. 06CZ016
通讯作者: 张树辉, 200437, 上海市甘河路110号, 上海中医药大学附属岳阳医院病理科. zhangshuhui100@sohu.com
电话: 021-65161782-2604
收稿日期: 2007-08-19 修回日期: 2007-10-29
Down-regulated expression of metallothionein and its clinicopathological significance in hepatocellular carcinoma
Shu-Hui Zhang, Ai-Min Xu
Shu-Hui Zhang, Department of Pathology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
Ai-Min Xu, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
Supported by: the Research Foundation from Shanghai Municipal Education Commission, No. 06CZ016
Correspondence to: Shu-Hui Zhang, Department of Pathology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, China. zhangshuhui100@sohu.com
Received: 2007-08-19 Revised: 2007-10-29
Abstract
AIM: To investigate the expression and loca-lization of metallothionein (MT) and their association with clinicopathological characteristics in hepatocellular carcinoma (HCC).
METHODS: Four hundred histological specimens of HCC with corresponding non-cancerous liver tissues were immunohistochemically stained for MT (E9), P53 and Ki-67 by EnVision Plus staining using tissue microarrays.
RESULTS: Down-regulated expression of MT protein was detected in HCC, compared with non-cancerous liver tissues. The frequency of MT positivity was significantly lower in cases positive for hepatitis B surface antigen than in those that were negative (P = 0.042). The positive rate of MT expression was higher in tumors ≤ 2 cm than > 2 cm in diameter (P = 0.007). There was a tendency for MT expression to decrease with the progression of histological grade (P = 0 ......
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