粒细胞集落刺激因子防治小鼠CCl4所致肝损伤的作用
粒细胞集落刺激因子;骨髓干细胞;肝损伤修复;Y染色体,粒细胞集落刺激因子防治小鼠CCl4所致肝损伤的作用,王君平,孙殿兴,李敏然,郭争荣,亢继文,李兵顺,李伟勇,王君平,通讯作者:,EffectofgranulocytecolonystimulatingfactoronrepairofCCl
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王君平, 孙殿兴, 李敏然, 郭争荣, 亢继文, 白求恩国际和平医院肝病科 河北省石家庄市 050082
李兵顺, 石家庄市传染病医院肝病四科 河北省石家庄市 050021
李伟勇, 白求恩国际和平医院传染科 河北省石家庄市 050082
王君平, 2006年河北医科大学硕士研究生毕业, 主治医师, 主要从事乙型病毒性肝炎的研究.
河北省科技攻关题资助项目, No. 052761262
通讯作者: 孙殿兴, 050082, 河北省石家庄市, 白求恩国际和平医院肝病科. sundianxing@hotmail.com
电话: 0311-87978436
收稿日期: 2007-07-17 修回日期: 2007-10-10
Effect of granulocyte colony stimulating factor on repair of CCl4-induced liver injury in mice
Jun-Ping Wang, Dian-Xing Sun, Bing-Shun Li, Min-Ran Li, Zheng-Rong Guo, Ji-Wen Kang, Wei-Yong Li
Jun-Ping Wang, Dian-Xing Sun, Min-Ran Li, Zheng-Rong Guo, Ji-Wen Kang, Department of Liver Diseases, Bethune International Peace Hospital, Shijiazhuang 050082, Hebei Province, China
Bing-Shun Li, the Fourth Department of Liver Diseases, Shijiazhuang Infectious Disease Hospital, Shijiazhuang 050021, Hebei Province, China
Wei-Yong Li, Department of Infectious Disease, Bethune International Peace Hospital, Shijiazhuang 050082, Hebei Province, China
Supported by: the Research Foundation of Science and Technology of Hebei Province, China, No. 052761262
Correspondence to: Dian-Xing Sun, Department of Liver Diseases, Bethune International Peace Hospital, Shijiazhuang 050082, Hebei Province, China. sundianxing@hotmail.com
Received: 2007-07-17 Revised: 2007-10-10
Abstract
AIM: To observe the effect of recombinant human granulocyte colony stimulating factor (rhG-CSF) on repair of CCl4-induced liver injury in mice, and to investigate the homing ability of peripheral blood stem cells mobilized by rhG-CSF to localize in the injured liver.
METHODS: Liver injury was induced by 400 mL/L CCl4 2 mL/kg in clean BALB/c mice twice a week and then treated. Then, with rhG-CSF 200 µg/kg sc. The mortality rate and liver pathology changes and liver functions and other factors were analyzed ......
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