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编号:11581710
原发性肝癌组织芯片中乙酰肝素酶的表达及意义
http://www.100md.com 陈 罡, 党裔武, 罗殿中, 冯震博, 唐小玲
乙酰肝素酶;癌;肝细胞;免疫组织化学;组织芯片,陈罡,党裔武,罗殿中,冯震博,唐小玲,通讯作者:,Expressionofheparanaseintissuemicroarraysofprimaryhepatocellularcarcinomaandit
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     陈罡, 党裔武, 罗殿中, 冯震博, 唐小玲, 广西医科大学病理教研室 第一附属医院病理科 广西壮族自治区南宁市 530021

    中国高等学校博士学科点专项科研基金项目资助, No. 20050598005

    广西科学研究与技术开发计划应用基础研究项目资助, No. 0639040

    通讯作者: 罗殿中, 530021, 广西壮族自治区南宁双拥路, 广西医科大学病理教研室, 广西医科大学第一附属医院病理科. luodianzhong@yahoo.com.cn

    电话: 0771-5356534 传真: 0771-5358502

    收稿日期: 2007-07-12 修回日期: 2007-11-03

    Expression of heparanase in tissue microarrays of primary hepatocellular carcinoma and its significance

    Gang Chen, Yi-Wu Dang, Dian-Zhong Luo, Zhen-Bo Feng, Xiao-Ling Tang


    

    Gang Chen, Yi-Wu Dang, Dian-Zhong Luo, Zhen-Bo Feng, Xiao-Ling Tang,
Department of Pathology, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China

    Supported by: Chinese University PhD Division Special Science Research Fund Project, No. 20050598005; Science Research and Technology Exploitation Program Application Basic Research Projects of Guangxi, No. 0639040

    Correspondence to: Dian-Zhong Luo, Department of Pathology, Guangxi Medical University, Shuangyong Road, Nanjing 530021, Guangxi Zhuang Autonomous Region, China. luodianzhong@yahoo.com.cn

    Received: 2007-07-12 Revised: 2007-11-03

    

    Abstract

    AIM:
To investigate the expression of heparanase in tissue microarrays of hepatocellular carcinoma (HCC), and its clinical significance.

    METHODS:
Tissue microarrays comprised 125 tissues from HCC, 48 from tumor-adjacent liver, 62 from cirrhosis, and 23 from normal liver. Immunohistochemistry was employed to detect the expression of heparanase. Correlation between the expression and clinicopathological features of HCC was analyzed statistically.

    

    RESULTS:
The positive rate of HPA in HCC tissues (45.83%) was significantly higher than that in the adjacent-tumor liver (27.08%) (χ2 = 2.23, P < 0.05, cirrhosis (6.45%) (χ2 = 5.262,P < 0.05) and normal liver tissues (4.35%) (χ2 = 3.895, P < 0 ......

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