超分子铂类药物西茜铂体内外对消化系肿瘤的抑制作用
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王士勇, 杨振君, 于 环, 杨云锋, 张 晖, 王敬尊
消化系统;肿瘤;西茜铂;卡铂,王士勇,于环,杨云锋,张晖,杨振君,王敬尊,王士勇,通讯作者:,InhibitoryeffectsofsupramolecularplatinumcompoundCCPondigestivetumors,Shi-
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王士勇, 于环, 杨云锋, 张晖, 中国医科大学附属第四医院生物治疗科 辽宁省沈阳市 110032
杨振君, 中国医科大学附属第二医院信息科 辽宁省沈阳市110004
王敬尊, 北京三思维尔高科技开发有限公司 北京市 100005
王士勇, 博士、博士后, 副教授, 主要从事肿瘤生物治疗和干细胞移植.
教育部归国博士启动课题, No. 2004-527, No. 2004-231
通讯作者: 王士勇, 110032, 辽宁省沈阳市于洪区崇山东路4号, 中国医科大学附属第四医院生物治疗科和中心实验室.
sywang66@yahoo.com
电话: 024-62043763 传真: 024-62571119
收稿日期: 2007-06-29 修回日期: 2007-09-24
Inhibitory effects of supramolecular platinum compound CCP on digestive tumors
Shi-Yong Wang, Zhen-Jun Yang, Huan Yu, Yun-Feng Yang, Hui Zhang, Jing-Zun Wang
Shi-Yong Wang, Huan Yu, Yun-Feng Yang, Hui Zhang, Department of Cancer Biotherapy, Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China
Zhen-Jun Yang, Department of Communication, Second Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Jing-Zun Wang, Beijing Sansiweier Explore Limited Company, Beijing 100005, China
Supported by: the Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry, No. 2004-527 and No. 2004-231
Correspondence to: Dr. Shi-Yong Wang, Department of Cancer Biotherapy, Fourth Affiliated Hospital of China Medical University, 4 Chongshan East Road, Yuhong District, Shenyang 110032, Liaoning Province,China. sywang66@yahoo.com
Received: 2007-06-29 Revised: 2007-09-24
Abstract
AIM: To investigate in vivo and in vitro inhibitory effects of a supramolecular drug-platinum compound CCP on digestive tumors.
METHODS: Six digestive tumor cell lines, hepatocellular carcinoma (BEL7402), gastric carcinoma (MG803 and SG7901), pancreatic carcinoma (BXCP-3 and JF305), and colon carcinoma (CX-1), were used to test the IC50 of CCP and carboplatin. H22-bearing Kunming mice and JE305-bearing nude mice were treated intraperitoneally with CCP at 10, 15 or 20 mg/kg ......
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