Galectin-3在CCl4致肝损伤及对GRP78调控的作用
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张 鸿, 具英花, 刘晓湘, 平贺紘一, 方秀斌
Galectin-3;四氯化碳;肝损伤;葡萄糖调节蛋白78,Galectin-3在CCl4致肝损伤及对GRP78调控的作用,张鸿,具英花,刘晓湘,方秀斌,平贺紘一,张鸿,通讯作者:,Roleofgalectin-3inCCl4-inducedhepaticdamageandinmodulati
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张鸿, 具英花, 刘晓湘, 方秀斌, 中国医科大学基础医学院神经生物学教研室 辽宁省沈阳市 110001
平贺紘一, 日本富山医科药科大学医学部生化讲座 日本富山 930-0194
张鸿, 1987年中国医科大学本科毕业, 1996年中国医科大学硕士研究生毕业, 2006年中国医科大学博士研究生毕业, 讲师, 主要从事肝损伤与修复机制研究.
通讯作者: 方秀斌, 110001, 辽宁省沈阳市和平区北二马路92号, 中国医科大学基础医学院神经生物学教研室.
xbfang@mail.cmu.edu.cn
电话: 024-23256666-5512
收稿日期: 2007-01-29 修回日期: 2007-10-17
Role of galectin-3 in CCl4-induced hepatic damage and in modulation of GRP78 in mice
Hong Zhang, Ying-Hua Ju, Xiao-Xiang Liu, Koichi Hiraga, Xiu-Bin Fang
Hong Zhang, Ying-Hua Ju, Xiao-Xiang Liu, Xiu-Bin Fang, Department of Neurobiology, Basic Medical College, China Medical University, Shenyang 110001, Liaoning Province, China
Koichi Hiraga, Department of Biochemistry, School of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan
Correspondence to: Dr. Xiu-Bin Fang, Department of Neurobiology, Basic Medical College, China Medical University, 92 Beier Road, Heping District, Shenyang 110001, Liaoning Province, China. xbfang@mail.cmu.edu.cn
Received: 2007-01-29 Revised: 2007-10-17
Abstract
AIM: To evaluate the role of galectin-3 in CC14-induced liver damage and in modulation of Glucose regulated protein 78 (GRP78) in mice.
METHODS: Ten-week-old, Gal-3 (–/–) and Gal-3 (+/+) ICR male mice were treated with CCl4 (8 mL/kg) by lavage. Mice were killed at 0, 10, 24, 48 and 72 h after CCl4 administration. Pathological changes in the liver, serum activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and expression of GRP78 protein in different parts of the liver were examined.
RESULTS: Pathological changes induced by CCl4 in the liver of Gal-3 (–/–) mice were earlier and more serious than those in Gal-3 (+/+) mice. Serum activity of ALT in Gal-3 (–/–) mice was higher than that in Gal-3 (+/+) mice at 10 and 24 h after treatment with CCl4 (1860 ± 191 U/L vs 1356 ± 177 U/L, t = 6 ......
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