中国辽宁地区人群幽门螺杆菌感染菌株与相关性胃疾病的关系
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宫月华, 柳云恩, 孙丽萍, 董楠楠, 袁 媛
幽门螺杆菌;相关性胃疾病;萎缩性胃炎;聚合酶链反应,宫月华,柳云恩,孙丽萍,董楠楠,袁媛,宫月华,通讯作者:,RelationshipbetweenHelicobacterpyloriinfectionandassociatedgastri
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宫月华, 柳云恩, 孙丽萍, 董楠楠, 袁媛, 中国医科大学附属第一医院肿瘤研究所第三研究室 辽宁省沈阳市 110001
宫月华, 2003年毕业于中国医科大学肿瘤学硕士, 助理研究员, 主要从事消化道胃癌病因、早期诊断及综合防治研究.
国家十五科技攻关基金资助项目, No. 2004BA703B04-2
国家自然科学基金资助项目, No. 30572131
通讯作者: 袁媛, 110001, 辽宁省沈阳市和平区南京北街155号, 中国医科大学附属第一医院肿瘤研究所第三研究室.
yyuan@mail.cmu.edu.cn
电话: 024-83282153 传真: 024-83282292
收稿日期: 2007-04-10 修回日期: 2007-10-10
Relationship between Helicobacter pylori infection and associated gastric diseases in Liaoning Province of China
Yue-Hua Gong, Yun-En Liu, Li-Ping Sun, Nan-Nan Dong, Yuan Yuan
Yue-Hua Gong, Yun-En Liu, Li-Ping Sun, Nan-Nan Dong, Yuan Yuan, the Third Department of Cancer Institute of the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Supported by: the National Key Technologies R&D Program of China during the 10th Five-Year Plan Period, No. 2004BA703B04-2 and National Natural Science Foundation of China, No. 30572131
Correspondence to: Professor Yuan Yuan, Cancer Institute of the First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. yyuan@mail.cmu.edu.cn
Received: 2007-04-10 Revised: 2007-10-10
Abstract
AIM: To explore the relationship between Helicobacter pylori infection and associated gastric diseases.
METHODS: Gastric biopsies were taken from 491 subjects, which were divided into supreficial gastritis (GS), atrophic gastritis (GA), gastric ulcer (GU) and gastric cancer (GC) groups, and 222 H pylori strains isolated from these patients were studied by PCR for differences in their genotypes cagA, vacA, and iceA. Three biopsies were taken for pathological diagnosis, from the gastric antrum, corpus and angularis, respectively.
RESULTS: The H pylori m2 infection rate in GA, GU and GC groups was 43.1%, 18.2% and 17.9%, respectively, and there was a statistical difference (P = 0 ......
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