阑尾切除与克罗恩病的关系
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刘 旭, 蔡小鹏, 田 丰, 董 卫
阑尾切除;克罗恩病;Meta分析;病例对照试验,刘旭,蔡小鹏,田丰,董卫,通讯作者:,AppendectomyandCrohn'sdisease,XuLiu,Xiao-PengCai,FengTian,WeiDong,Correspondenceto:,Recei
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刘旭, 蔡小鹏, 田丰, 中国医科大学附属盛京医院消化内科 辽宁省沈阳市 110004
董卫, 中国医科大学附属第一医院临床流行病教研室 辽宁省沈阳市 110001
通讯作者: 刘旭, 110004, 辽宁省沈阳市, 中国医科大学附属盛京医院消化内科. valentine1120@126.com
电话: 024-83956986
收稿日期: 2007-06-21 修回日期: 2007-11-17
Appendectomy and Crohn's disease
Xu Liu, Xiao-Peng Cai, Feng Tian, Wei Dong
Xu Liu, Xiao-Peng Cai, Feng Tian, Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China
Wei Dong, Department of Clinical Epidemiology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
Correspondence to: Xu Liu, Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China. valentine1120@126.com
Received: 2007-06-21 Revised: 2007-11-17
Abstract
AIM: To identify the relationship between appendectomy and Crohn's disease and the pathogenesis of Crohn's disease.
METHODS: We performed a meta-analysis of case-control studies on the relationship between appendectomy and Crohn's disease published domestically and abroad from January 1987 to May 2007.
RESULTS: Twelve case-control studies collectively gathered evidence from 11 058 patients and 784 440 controls. The results from the individual studies gave an overall odds ratio (OR) of 1.66 [95% confidence interval (CI) 1.32–2.09]. Stratification indicated a significant difference between the incident (OR = 1.22, 95% CI 0.77–1.95) and prevalent cases (OR = 1.82, 95% CI 1.38–2.14), and between the childhood group (OR = 1.16, 95% CI 0.94–1.44) and adult groups (OR = 2.15, 95% CI 1.85–2.50).
CONCLUSION: The meta-analysis suggests there is a positive association between appendectomy and Crohn's disease. Further studies are needed to establish whether a causal relationship exists.
Key Words: Appendectomy; Crohn's disease; Meta-analysis; Case-control studies ......
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