当前位置: 首页 > 期刊 > 《世界华人消化杂志》 > 2007年第34期
编号:11581684
肝转移性胃肠道间质瘤临床病理分析15例
http://www.100md.com 朱红波, 张秀辉, 廖殿英, 李俸媛
肝脏肿瘤;胃肠道间质瘤;临床病理特征,朱红波,张秀辉,廖殿英,李俸媛,通讯作者:,Clinicopathologicalanalysisofhepaticmetastaticgastrointestinalstromaltumors:ananalysisof
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     朱红波, 张秀辉, 廖殿英, 李俸媛, 四川大学华西医院病理科 四川省成都市 610041

    通讯作者: 张秀辉, 610041, 四川省成都市国学巷37号, 四川大学华西医院病理科. zhangxiuhui1955@126.com

    电话: 028-85422020

    收稿日期: 2007-06-21 修回日期: 2007-11-24

    Clinicopathological analysis of hepatic metastatic gastrointestinal stromal tumors: an analysis of 15 cases

    Hong-Bo Zhu, Xiu-Hui Zhang, Dian-Ying Liao, Feng-Yuan Li

    Hong-Bo Zhu, Xiu-Hui Zhang, Dian-Ying Liao, Feng-Yuan Li, Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China

    Correspondence to: Xiu-Hui Zhang, Department of Pathology, West China Hospital, Sichuan University, 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China. zhangxiuhui1955@126.com

    Received: 2007-06-21 Revised: 2007-11-24

    Abstract

    AIM: To study the clinicopathological and immunophenotypical features of hepatic metastatic gastrointestinal stromal tumors (GISTs).

    METHODS: Clinical and pathological data of 15 patients with hepatic metastatic GISTs were analyzed, and the related literature was reviewed.

    RESULTS: The tumors mainly originated from the small bowel (6/15) and stomach (5/15). The length of time after surgical treatment of the primary tumor to detection of a hepatic metastatic tumor was 0 d-86 mo (mean 25 mo ± 9 mo). Tumor size varied from 1.5 cm to 30.0 cm (mean 7.1 cm ± 1.2 cm). Cystification, hemorrhage or necrosis was observed in 6 tumors. Histologically, 11 were of the spindle cell type, 2 the epithelioid cell type and 2 mixture type. CD117 and CD34 showed diffuse expression, with a positive rate of 86.7% and 46.7%, respectively. Some cases were focally positive for SMA (33.3%) and S-100 (20%). Desmin was negative in all the 15 tumors.

    CONCLUSION: The liver is the most metastatic site of GISTs. The most common primary sites of hepatic metastatic GISTs are the small bowel and stomach. Hepatic metastatic GISTs have similar clinical and pathological features as primary GISTs, and a poor prognosis ......

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