血清巨噬细胞抑制因子-1在胰腺癌临床检测诊断中的应用价值
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邵长君, 王小兵, 汪 毅, 李 茉, 田海梅, 单 毅, 赵 平, 张 伟
胰腺癌;巨噬细胞抑制因子;CA199;酶联免疫方法,邵长君,王小兵,李茉,田海梅,张伟,汪毅,单毅,赵平,通讯作者:,Valueofmacrophageinhibitorycytokine-1asanovelmarkerfordetect
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邵长君, 王小兵, 李茉, 田海梅, 张伟, 中国协和医科大学中国医学科学院肿瘤医院肿瘤研究所生物检测中心 北京市 100021
汪毅, 单毅, 赵平, 中国协和医科大学中国医学科学院肿瘤医院腹部外科 北京市 100021
国家十五攻关资助项目, No. 2004BA703B11
国家高技术研究发展计划(863计划)资助项目, No. 2007AA02Z485
通讯作者: 张伟, 100021, 北京市, 中国协和医科大学中国医学科学院肿瘤医院肿瘤研究所生物检测中心.
zhangww1954@126.com
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收稿日期: 2007-06-13 修回日期: 2007-10-24
Value of macrophage inhibitory cytokine-1 as a novel marker for detecting and diagnosing pancreatic cancer
Chang-Jun Shao, Xiao-Bing Wang, Yi Wang, Mo Li, Hai-Mei Tian, Yi Shan, Ping Zhao, Wei Zhang
Chang-Jun Shao, Xiao-Bing Wang, Mo Li, Hai-Mei Tian, Wei Zhang, Tumor Marker Research Center, Cancer Institute and Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China
Yi Wang, Yi Shan, Ping Zhao, Department of Abdominal Surgical Oncology, Cancer Institute and Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China
Supported by: the National Key Technologies R&D Program of China During the 10th Five-year Plan Period, No. 2004BA703B11 and Hi-Tech Research and Development Program of China (863 Program), No. 2007AA02Z485
Correspondence to: Wei Zhang, Tumor Marker Research Center, Cancer Institute and Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China. zhangww1954@126.com
Received: 2007-06-13 Revised: 2007-10-24
Abstract
AIM: To evaluate the value of serum macrophage inhibitory cytokine-1 (MIC-1) as a novel marker for diagnosing pancreatic cancer.
METHODS: Serum MIC-1 levels were measured by sandwich ELISA assay in 101 patients with pancreatic adenocarcinomas, 10 patients with benign pancreatic tumors, and 50 healthy control subjects. The diagnostic performance of serum MIC-1 as a marker of pancreatic cancer was compared with that of serum CA199 ......
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