清胰汤对大鼠急性胰腺炎肺损伤时SP-A表达的影响
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张雪梅, 陈海龙, 王朝晖
急性重症胰腺炎;急性肺损伤;肺表面活性蛋白A;逆转录聚合酶链式反应,张雪梅,陈海龙,王朝晖,通讯作者:,InfluenceofQingyitangonsurfactantproteinAexpressioninsevereacutepancrea
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张雪梅, 陈海龙, 大连医科大学附属一院普外科 辽宁省大连市 116011
王朝晖, 大连医科大学附属二院消化内科 辽宁省大连市 116027
国家自然科学基金资助项目, No. 90709005
通讯作者: 陈海龙, 116011, 辽宁省大连市西岗区中山路222号, 大连医科大学附属第一医院普外科. hailongchen2006@126.com
电话: 0411-83634153 传真: 0411-83622844
收稿日期: 2007-08-04 修回日期: 2007-10-29
Influence of Qingyitang on surfactant protein A expression in severe acute pancreatitis-induced lung injury in rats
Xue-Mei Zhang, Hai-Long Chen, Zhao-Hui Wang
Xue-Mei Zhang, Hai-Long Chen, Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Zhao-Hui Wang, Department of Gastroenterology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China
Supported by: National Natural Science Foundation of China, No. 90709005
Correspondence to: Hai-Long Chen, Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Xigang District, Dalian 116011, Liaoning Province, China. hailongchen2006@126.com
Received: 2007-08-04 Revised: 2007-10-29
Abstract
AIM: To investigate the expression of surfactant protein A (SP-A) in the lungs of rats with severe acute pancreatitis (SAP), and the effect of Qingyitang on acute lung injury (ALI) induced by SAP.
METHODS: SD rats were randomly divided into sham-operation group (SO, n = 10), SAP model group (SAP, n = 10) and Qingyitang group (QYT, n = 10). Severe acute pancreatitis was induced in the SAP and QYT groups. Sham operations were only performed on rats in the SO group. QYT (10 mL/kg) was intragastrically administered 30 min and 12 hours after SAP was induced in the QYT group. Serum amylase (AMY) levels, PaO2 and lung wet/dry ratio (W/D) were determined. The level of SP-A mRNA expression in lung was detected by reverse transcription polymerase chain reaction (RT-PCR) ......
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