前列地尔注射液联合血浆置换治疗重型肝炎33例

http://www.100md.com 陈礼宏, 李德辉, 杨春芳

前列地尔;重型肝炎;血浆置换,陈礼宏,李德辉,杨春芳,通讯作者:,ProstaglandinE1combinedwithplasmaexchangefortreatmentofpatientswithseverehepatitis:ananalysis

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     陈礼宏, 李德辉, 杨春芳, 常德市第一人民医院传染科 湖南省常德市 415003

    通讯作者: 陈礼宏, 415003, 湖南省常德市第一人民医院传染科. clh1997119@sina.com

    收稿日期: 2007-05-31 修回日期: 2007-11-30

    Prostaglandin E1 combined with plasma exchange for treatment of patients with severe hepatitis: an analysis of 33 cases

    Li-Hong Chen, De-Hui Li, Chun-Fang Yang

    

    Li-Hong Chen, De-Hui Li, Chun-Fang Yang, Department of Infectious Diseases, the First People's Hospital of Changde City, Changde 415003, Hu’nan Province, China

    Correspondence to: Li-Hong Chen, Department of Infectious Diseases, the First People's Hospital of Changde City, Changde 415003, Hu’nan Province, China. clh1997119@sina.com

    Received: 2007-05-31 Revised: 2007-11-30

    

    Abstract

    AIM: To evaluate the therapeutic effects of prostaglandin E1 (PGE1) combined with plasma exchange in patients with severe hepatitis.

    

    METHODS: Sixty-two patients with severe hepatitis were randomly divided into treatment (n = 33) and control (n = 29) groups. In the treatment group, 33 patients with severe hepatitis (two with subacute severe hepatitis, and 31 with chronic severe hepatitis) received combined therapy with comprehensive internal medicine treatment which was the artificial liver support system and PGE1. In the control group, 29 patients (one with subacute severe hepatitis, and 28 with chronic severe hepatitis) were treated with comprehensive internal medicine and the artificial liver support system.

    

    RESULTS: After treatment, serum total bilirubin, alanine aminotransferase, and PTA were significantly improved in the two groups. There were significant differences between the treatment and control group in concentration of TBIL and PTA (155.8 ± 138.2 µmol/L vs 296.4 ± 100.5 µmol/L; 62.6% ± 10.4% vs 42.9% ±11.4%; P < 0.01). The survival rate in the treatment group was higher than that in the control group (72.8% vs 48.3%, P < 0.01).

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