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作者：张永文 陈玉武 赵世萍
山茱萸|山茱萸科|7-O-没食子酰-D-景天庚酮糖|D-景天庚酮糖
作者：张永文 陈玉武 赵世萍
单位：中日友好临床医学研究所，北京 100029
关键词：山茱萸；山茱萸科；7-O-没食子酰-D-景天庚酮糖；D-景天庚酮糖
药学学报990218 A SEDOHEPTULOSE GALLATE FROM THE FRUITS
OF CORNUS OFFICINALIS
Zhang Yongwen (Zhang YW), Chen Yuwu (Chen YW) and Zhao Shiping (Zhao SP)
(China-Japan Frienship Institute of Clinical Medical Sciences, Beijing 100029)
ABSTRACT AIM: To investigate the chemical constituents of the plant drug Cornus officinalis Sieb et Zucc. which is widely used in Chinese traditional medicine, having actions of invigorating the liver and kidney, strengthening the body, and of an astringent, etc. METHODS: A sedoheptulose gallate was isolated from the water extracts of fruits of C.officinalis using various chromatographies. The structure determination was based on spectral (UV, IR, 1H & 13CNMR and MS) and chemical evidence. RESULTS: Its structure was characterized to be 7-O-galloyl-D-sedoheptulose (I). The proportion of its three major conformation forms of β-F, α-F and α-P in aqueous solution was estimated to be 57∶24∶19 according to their C-1 peak heights in the 13CNMR spectrum. CONCLUSION: I was found in natural world for the first time and its β-D-heptufuranosyl form was the predominant existing tautomer in its equilibrated aqueous solution according to NMR determination. ......
单位：中日友好临床医学研究所，北京 100029
关键词：山茱萸；山茱萸科；7-O-没食子酰-D-景天庚酮糖；D-景天庚酮糖
药学学报990218 A SEDOHEPTULOSE GALLATE FROM THE FRUITS
OF CORNUS OFFICINALIS
Zhang Yongwen (Zhang YW), Chen Yuwu (Chen YW) and Zhao Shiping (Zhao SP)
(China-Japan Frienship Institute of Clinical Medical Sciences, Beijing 100029)
ABSTRACT AIM: To investigate the chemical constituents of the plant drug Cornus officinalis Sieb et Zucc. which is widely used in Chinese traditional medicine, having actions of invigorating the liver and kidney, strengthening the body, and of an astringent, etc. METHODS: A sedoheptulose gallate was isolated from the water extracts of fruits of C.officinalis using various chromatographies. The structure determination was based on spectral (UV, IR, 1H & 13CNMR and MS) and chemical evidence. RESULTS: Its structure was characterized to be 7-O-galloyl-D-sedoheptulose (I). The proportion of its three major conformation forms of β-F, α-F and α-P in aqueous solution was estimated to be 57∶24∶19 according to their C-1 peak heights in the 13CNMR spectrum. CONCLUSION: I was found in natural world for the first time and its β-D-heptufuranosyl form was the predominant existing tautomer in its equilibrated aqueous solution according to NMR determination. ......