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作者：史海健 王忠义 史好新
3,6-二芳基-1,2,4-三唑并[3,4-B]-1,3,4-噻二唑|合成|生物活性,3-芳基,芳氧甲基-6-芳基-1,2,4-三唑并[3,4-B]-1,3,4-噻二唑衍生物的合成及生物活性
作者：史海健 王忠义 史好新
单位：史海健 史好新 安徽师范大学化学系，芜湖 241000；王忠义 中国科技大学化学系，合肥 230026
关键词：3,6-二芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑；合成；生物活性
药学学报990217 SYNTHESIS AND BIOLOGICAL ACTIVITIES OF DERIVATIVES OF
3-ARYL/ARYLOXYMETHYL-6-ARYL-1,2,4-TRIAZOLO[3,4-B]-1,3,4-THIADIAZOLES
Shi Haijian (Shi HJ) and Shi Haoxin (Shi HX)
Department of Chemistry, Anhui Normal University, Wuhu 241000
Wang Zhongyi (Wang ZY)
Department of Chemistry, The University of Science and Technology of China, Hefei 230026
ABSTRACT AIM: To synthesize a number of novel heterocyclic compounds and screen for their biological activities. Sixteen title compounds were prepared. METHODS: These novel compounds were prepared by the reaction of 3-aryl/aryloxymethyl-4-amino-5-mercapto-1,2,4-triazoles with aryl carboxylic acids in the presence of phosphorus oxychloride. The structures of these compounds were confirmed by elemental analysis, IR, 1HNMR and MS. The reaction conditions for the synthesis had been investigated. All the compounds were screened for antimicrobial activity against bacteria S.aureus, E.coli and B.subilis. The concentration of the test compounds was 0.002%. The antibacterial activities of the test compounds were compared with those of penicillin and gentamicin. RESULTS: The results display that some of them possess strong biological activities.CONCLUSION: Syntheses of these novel heterocyclic compounds and study on their biological activities are very important and valuable in medicine. ......
单位：史海健 史好新 安徽师范大学化学系，芜湖 241000；王忠义 中国科技大学化学系，合肥 230026
关键词：3,6-二芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑；合成；生物活性
药学学报990217 SYNTHESIS AND BIOLOGICAL ACTIVITIES OF DERIVATIVES OF
3-ARYL/ARYLOXYMETHYL-6-ARYL-1,2,4-TRIAZOLO[3,4-B]-1,3,4-THIADIAZOLES
Shi Haijian (Shi HJ) and Shi Haoxin (Shi HX)
Department of Chemistry, Anhui Normal University, Wuhu 241000
Wang Zhongyi (Wang ZY)
Department of Chemistry, The University of Science and Technology of China, Hefei 230026
ABSTRACT AIM: To synthesize a number of novel heterocyclic compounds and screen for their biological activities. Sixteen title compounds were prepared. METHODS: These novel compounds were prepared by the reaction of 3-aryl/aryloxymethyl-4-amino-5-mercapto-1,2,4-triazoles with aryl carboxylic acids in the presence of phosphorus oxychloride. The structures of these compounds were confirmed by elemental analysis, IR, 1HNMR and MS. The reaction conditions for the synthesis had been investigated. All the compounds were screened for antimicrobial activity against bacteria S.aureus, E.coli and B.subilis. The concentration of the test compounds was 0.002%. The antibacterial activities of the test compounds were compared with those of penicillin and gentamicin. RESULTS: The results display that some of them possess strong biological activities.CONCLUSION: Syntheses of these novel heterocyclic compounds and study on their biological activities are very important and valuable in medicine. ......