Graves’病患者血清可溶性Fas检测及其临床意义
作者：王加林 赵亚平 吴合军 颜萍 吴正和., http://www.100md.com
单位：解放军第82医院内分泌专科中心，江苏 淮阴 223001., http://www.100md.com
关键词：可溶性Fas(sFas)； Graves’病., http://www.100md.com
免疫学杂志010116 摘 要：目的 探讨可溶性Fas(sFas)在Graves’病(GD)发病过程中的作用。方法 应用夹心酶联免疫吸附法(ELISA)，测定了68例GD患者和20例健康对照者sFas含量。结果 ①GD患者未治疗组和缓解组血清sFas水平高于健康对照组；②GD患者未治疗组和缓解组sFas.TRAb乘积高于健康对照组；③血清sFas与TRAb呈正相关关系，与游离T3、游离T4和促甲状腺素(TSH)无相关关系。结论 sFas参与了GD发病与转归的病理生理过程，可以作为GD病情监测的重要指标。., http://www.100md.com
分类号：R581.1 文献标识码：A., http://www.100md.com
文章编号：1000-8861(2001)01-0056-02., http://www.100md.com
Measurement of serum soluble Fas in patients with Graves’ disease and its clinical significance., http://www.100md.com
WANG Jia-lin(Department of Internal Secretion，The 82th Hospital of PLA，Huaiyin 223001，China)., http://www.100md.com
ZHAO Ya-ping(Department of Internal Secretion，The 82th Hospital of PLA，Huaiyin 223001，China)., http://www.100md.com
WU He-jun(Department of Internal Secretion，The 82th Hospital of PLA，Huaiyin 223001，China)., http://www.100md.com
YAN Ping(Department of Internal Secretion，The 82th Hospital of PLA，Huaiyin 223001，China)
WU Zheng-he(Department of Internal Secretion，The 82th Hospital of PLA，Huaiyin 223001，China)do43/x4, 百拇医药
Abstract：Objective To investigate the concentration of soluble sFas(sFas) in Graves’disease(GD) and its clinical significance.Methods Serum levels of sFas in 68 cases of GD patients and 20 cases of healthy subjects were measured with a sandwiched ELISA method.Results ①Serum sFas levels of GD untreated group and remission group were much higher than those of healthy controls(2.08±0.82， 1.11±0.31 vs 0.70±0.5 0 ng/mL，P<0.001)；② Multiplier of sFas.TRAb in GD untreated group and remission group were much higher than those of healthy controls(80.01±57.62， 3.34±1.69 vs 0.81±0.80，P<0.001)；③The concentration of serum sFas was significantly correlated with anti-thyrotropin(TSH) receptor antibody titers(r＝0.309，P<0.05)，but not with other clinical parameters(free triiodothyronine，free thyroxine and TSH)(r＝0.041—0.146，P>0.05).Conclusion Serum sFas may play a pivotal role in the pathogenesis of GD.do43/x4, 百拇医药
Keywords：soluble Fas； Graves’diseasedo43/x4, 百拇医药
作者简介：王加林(1958-)，男，江苏涟水县人，主任医师，本科，主要从事自身免疫性甲状腺疾病免疫学发病机理的研究。do43/x4, 百拇医药
参考文献：do43/x4, 百拇医药
[1]Hiromatsu Y，Bednarczuk T，Soyejima E，et al. Increased serum soluble Fas in patients with Graves’disease[J]. Thyroid， 1999，9(4)：341-345.do43/x4, 百拇医药
[2]Shimaoka Y，Hidakay Y，Okumuram M， et al.Serum concentration of soluble Fas in patients with autoimmune thyroid diseases[J].Thyroid， 1998，8(1)：43-47.do43/x4, 百拇医药
[3]Kawakamim A，Eguchi K，Matsuoka N， et al. Thyroid-stimulating hormone inhibits Fas antigen-mediated apoptosis of human thyrocytes in vitro[J].Endocrinology， 1996，137(8)：3 163-3 169.do43/x4, 百拇医药
[4]Taminoto C，Hirakawa H，Kawasaki H，et al. Apoptosis in thyroid disease： a histological study[J].Endocrinol J，1995，42(2)：193-201.do43/x4, 百拇医药
收稿日期：2000年8月23日do43/x4, 百拇医药
修稿日期：2000年11月13日do43/x4, 百拇医药
出版日期：2001年1月15日(作者：王加林 赵亚平 吴合军 颜萍 吴正和)
单位：解放军第82医院内分泌专科中心，江苏 淮阴 223001., http://www.100md.com
关键词：可溶性Fas(sFas)； Graves’病., http://www.100md.com
免疫学杂志010116 摘 要：目的 探讨可溶性Fas(sFas)在Graves’病(GD)发病过程中的作用。方法 应用夹心酶联免疫吸附法(ELISA)，测定了68例GD患者和20例健康对照者sFas含量。结果 ①GD患者未治疗组和缓解组血清sFas水平高于健康对照组；②GD患者未治疗组和缓解组sFas.TRAb乘积高于健康对照组；③血清sFas与TRAb呈正相关关系，与游离T3、游离T4和促甲状腺素(TSH)无相关关系。结论 sFas参与了GD发病与转归的病理生理过程，可以作为GD病情监测的重要指标。., http://www.100md.com
分类号：R581.1 文献标识码：A., http://www.100md.com
文章编号：1000-8861(2001)01-0056-02., http://www.100md.com
Measurement of serum soluble Fas in patients with Graves’ disease and its clinical significance., http://www.100md.com
WANG Jia-lin(Department of Internal Secretion，The 82th Hospital of PLA，Huaiyin 223001，China)., http://www.100md.com
ZHAO Ya-ping(Department of Internal Secretion，The 82th Hospital of PLA，Huaiyin 223001，China)., http://www.100md.com
WU He-jun(Department of Internal Secretion，The 82th Hospital of PLA，Huaiyin 223001，China)., http://www.100md.com
YAN Ping(Department of Internal Secretion，The 82th Hospital of PLA，Huaiyin 223001，China)
WU Zheng-he(Department of Internal Secretion，The 82th Hospital of PLA，Huaiyin 223001，China)do43/x4, 百拇医药
Abstract：Objective To investigate the concentration of soluble sFas(sFas) in Graves’disease(GD) and its clinical significance.Methods Serum levels of sFas in 68 cases of GD patients and 20 cases of healthy subjects were measured with a sandwiched ELISA method.Results ①Serum sFas levels of GD untreated group and remission group were much higher than those of healthy controls(2.08±0.82， 1.11±0.31 vs 0.70±0.5 0 ng/mL，P<0.001)；② Multiplier of sFas.TRAb in GD untreated group and remission group were much higher than those of healthy controls(80.01±57.62， 3.34±1.69 vs 0.81±0.80，P<0.001)；③The concentration of serum sFas was significantly correlated with anti-thyrotropin(TSH) receptor antibody titers(r＝0.309，P<0.05)，but not with other clinical parameters(free triiodothyronine，free thyroxine and TSH)(r＝0.041—0.146，P>0.05).Conclusion Serum sFas may play a pivotal role in the pathogenesis of GD.do43/x4, 百拇医药
Keywords：soluble Fas； Graves’diseasedo43/x4, 百拇医药
作者简介：王加林(1958-)，男，江苏涟水县人，主任医师，本科，主要从事自身免疫性甲状腺疾病免疫学发病机理的研究。do43/x4, 百拇医药
参考文献：do43/x4, 百拇医药
[1]Hiromatsu Y，Bednarczuk T，Soyejima E，et al. Increased serum soluble Fas in patients with Graves’disease[J]. Thyroid， 1999，9(4)：341-345.do43/x4, 百拇医药
[2]Shimaoka Y，Hidakay Y，Okumuram M， et al.Serum concentration of soluble Fas in patients with autoimmune thyroid diseases[J].Thyroid， 1998，8(1)：43-47.do43/x4, 百拇医药
[3]Kawakamim A，Eguchi K，Matsuoka N， et al. Thyroid-stimulating hormone inhibits Fas antigen-mediated apoptosis of human thyrocytes in vitro[J].Endocrinology， 1996，137(8)：3 163-3 169.do43/x4, 百拇医药
[4]Taminoto C，Hirakawa H，Kawasaki H，et al. Apoptosis in thyroid disease： a histological study[J].Endocrinol J，1995，42(2)：193-201.do43/x4, 百拇医药
收稿日期：2000年8月23日do43/x4, 百拇医药
修稿日期：2000年11月13日do43/x4, 百拇医药
出版日期：2001年1月15日(作者：王加林 赵亚平 吴合军 颜萍 吴正和)