脱氧氟尿苷冻干粉针剂的抗肿瘤作用研究
郭青龙1, 郭殿武2 ,陈真1
(1中国药科大学生理学教研室，南京210009 ， 2杭州民生药业集团有限公司，杭州310011)
[摘 要] 目的：研究脱氧氟尿苷(DFUR)冻干粉针剂(DFURLP)对荷瘤小鼠的抗肿瘤活性。方法：以荷瘤小鼠的瘤重和生命延长率为指标，观察药物(300，150，75 mg.kg -1)的抗肿瘤活性。结果：DFURLP(300，150 mg.kg -1 iv)对小鼠移植性肉瘤180(S180)、肝瘤实体型(Heps)及子宫肉瘤(U14)的肿瘤生长具有明显的抑制作用(P<0.01＝, DFURLP(300 mg.kg –1,iv)与DFUR(600 mg.kg –1,ig)作用相近，DFURLP(300，150 mg.kg –1, ip)能显著延长S180、Heps、EAC腹水型小鼠移植瘤的存活天数，而DFUR(300 mg.kg –1,ig)对以上三种腹水瘤无明显延长生命作用。结论：实验研究结果表明，DFURLP iv及ip对动物实验性肿瘤具有显著的抑制作用。
, 百拇医药
[关键词] 脱氧氟尿苷冻干粉针剂；脱氧氟尿苷；抗肿瘤
[中图分类号]R979.12 [文献标识码]B [文章编号] 1003-3734(2001)
Study of the antitumor effect of doxifluridine
lyophilized powder for injection
GUO Qin-long1, GUO Dian-Wu2 CHEN Zhen 1
(1 Department of Physiology, China Pharmaceutical University, Nanjing 210009,China; 2 Hangzhou Minsheng Pharmaceutical Group Co. Ltd. 310011, China)
, 百拇医药
[Abstract] Objective: To study the effects of donxifluridine(DFUR) lyophilizied powder for injection(DFURLP) on the experimental tumors：S180、Heps and U14 in mice . Methods: The activity of DFUR(300,150,75mg.kg-1) was observed to measure the survival time of mice with the three ascitic type and the weight of the tumor. Result: The growth of S180、Heps and U14 in mice was significantly(p<0.01) inhibited by DFURLP. The effects of DFURLP (300mg/kg) following iv administration was similar to those of DFUR (600mg/kg) following ig administration. DFURLP(300，150mg/kg) following ip administration could significantly prolong the survival time of mice with S180，Heps of ascitic type and EAC，but DFUR (300mg/kg) following ig administration could not significantly prolong the survival time of mice with the three ascitic type. CONCLUSION: The experimental tumors(S180, Heps, and U14) in mice were significantly inhibited by DFURLP following iv or ip administration.
, 百拇医药
[Key words] doxifluridine lyophilized powder for injection；doxifluridine；antitumor
[作者简介] 郭青龙(1960-)，男，副教授，主要研究方向为抗肿瘤药物的研究。联系电话：(025)3271324。
[参 考 文 献]
[1] 夏路风，朱翊. 氟铁龙[J].中国新药杂志，1997，6(1):39-42.
[2]. 徐淑云，卡如廉，陈修. 药理学实验方法[M].北京：人民卫生出版社，1991. 1424.
[3] 后德辉，郭青龙，李运曼，等. 抗瘤八号对实验性肿瘤的治疗作用[J].中国药科大学学报，1989，20(6)：348-350
[4] Shuji Suzuki, Yoko Hongu, Hideo Fukazawa, et al. Tissue distribution of 5’-deoxy-5-fluorouridine and derived 5-fluorouracil in Tumor-bearing mice and rats[J]. Gann, 1980,70: 238., http://www.100md.com
(1中国药科大学生理学教研室，南京210009 ， 2杭州民生药业集团有限公司，杭州310011)
[摘 要] 目的：研究脱氧氟尿苷(DFUR)冻干粉针剂(DFURLP)对荷瘤小鼠的抗肿瘤活性。方法：以荷瘤小鼠的瘤重和生命延长率为指标，观察药物(300，150，75 mg.kg -1)的抗肿瘤活性。结果：DFURLP(300，150 mg.kg -1 iv)对小鼠移植性肉瘤180(S180)、肝瘤实体型(Heps)及子宫肉瘤(U14)的肿瘤生长具有明显的抑制作用(P<0.01＝, DFURLP(300 mg.kg –1,iv)与DFUR(600 mg.kg –1,ig)作用相近，DFURLP(300，150 mg.kg –1, ip)能显著延长S180、Heps、EAC腹水型小鼠移植瘤的存活天数，而DFUR(300 mg.kg –1,ig)对以上三种腹水瘤无明显延长生命作用。结论：实验研究结果表明，DFURLP iv及ip对动物实验性肿瘤具有显著的抑制作用。
, 百拇医药
[关键词] 脱氧氟尿苷冻干粉针剂；脱氧氟尿苷；抗肿瘤
[中图分类号]R979.12 [文献标识码]B [文章编号] 1003-3734(2001)
Study of the antitumor effect of doxifluridine
lyophilized powder for injection
GUO Qin-long1, GUO Dian-Wu2 CHEN Zhen 1
(1 Department of Physiology, China Pharmaceutical University, Nanjing 210009,China; 2 Hangzhou Minsheng Pharmaceutical Group Co. Ltd. 310011, China)
, 百拇医药
[Abstract] Objective: To study the effects of donxifluridine(DFUR) lyophilizied powder for injection(DFURLP) on the experimental tumors：S180、Heps and U14 in mice . Methods: The activity of DFUR(300,150,75mg.kg-1) was observed to measure the survival time of mice with the three ascitic type and the weight of the tumor. Result: The growth of S180、Heps and U14 in mice was significantly(p<0.01) inhibited by DFURLP. The effects of DFURLP (300mg/kg) following iv administration was similar to those of DFUR (600mg/kg) following ig administration. DFURLP(300，150mg/kg) following ip administration could significantly prolong the survival time of mice with S180，Heps of ascitic type and EAC，but DFUR (300mg/kg) following ig administration could not significantly prolong the survival time of mice with the three ascitic type. CONCLUSION: The experimental tumors(S180, Heps, and U14) in mice were significantly inhibited by DFURLP following iv or ip administration.
, 百拇医药
[Key words] doxifluridine lyophilized powder for injection；doxifluridine；antitumor
[作者简介] 郭青龙(1960-)，男，副教授，主要研究方向为抗肿瘤药物的研究。联系电话：(025)3271324。
[参 考 文 献]
[1] 夏路风，朱翊. 氟铁龙[J].中国新药杂志，1997，6(1):39-42.
[2]. 徐淑云，卡如廉，陈修. 药理学实验方法[M].北京：人民卫生出版社，1991. 1424.
[3] 后德辉，郭青龙，李运曼，等. 抗瘤八号对实验性肿瘤的治疗作用[J].中国药科大学学报，1989，20(6)：348-350
[4] Shuji Suzuki, Yoko Hongu, Hideo Fukazawa, et al. Tissue distribution of 5’-deoxy-5-fluorouridine and derived 5-fluorouracil in Tumor-bearing mice and rats[J]. Gann, 1980,70: 238., http://www.100md.com