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氮唑类抗真菌药物研究新进展
http://www.100md.com 2002年5月25日 新药网
     盛春泉, 季海涛, 张万年

    [摘要] 近年来氮唑类抗真菌药物研究取得了许多新进展。氮唑类药物的作用机制得到了进一步阐明,并有多个广谱、低毒、高效的新化合物进入临床研究。本文综述了氮唑类抗真菌药物作用机制的研究进展,并介绍了5个正在研制中的新型氮唑类抗真菌药物 :活力康唑、普沙康唑、拉夫康唑、Syn-2869和TAK-187。与临床上常用的氟康唑和伊曲康唑相比,这5个新化合物均有其显著的优点。

    [关键词]抗真菌 ;活力康唑 ;普沙康唑; 拉夫康唑

    New Progress in Azole Antifungal Drug Research

    Sheng Chunquan, Ji Haitao ,Zhang wangnian

    (College of Pharmacy, Second Military Medical University , Shanghai 200433)
, 百拇医药
    [Abstract] There have been many new developments in azole antifungal drug reseach. The mechanism of azole antifungals has been further clarified. Moreover, several new compounds with broad spectrum, low toxicity and high efficiency are undergoing clinical trials. New progress in the mole of action of azole antifungals is reviewed. Five novel azole antifungal drugs (Voriconazole, Posaconazole, Ravuconazole, Syn-2869 and TAK-187) are also introduced. The five new compounds have remarkable advantages as compared with fluconazole and itraconazole which are widely used in clinical practice now.
, 百拇医药
    [Keywords] Antifungal; Voriconazole ;Posaconazole; Ravuconazole

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