美国科学家发现可以逆转自身免疫性糖尿病小鼠的退化的胰岛
编者按：这一发现是发于本周science，首次发现胰岛的退化能被逆转，为I型糖尿病的治疗提供了曙光!
Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice
Shohta Kodama, Willem Kühtreiber, Satoshi Fujimura, Elizabeth A. Dale, Denise L. Faustman*
Science, Volume 302, Number 5648, Issue of 14 Nov 2003, pp. 1223-1227
Nonobese diabetic (NOD) mice are a model for type 1 diabetes in humans. Treatment of NOD mice with end-stage disease by injection of donor splenocytes and complete Freund's adjuvant eliminates autoimmunity and permanently restores normoglycemia. The return of endogenous insulin secretion is accompanied by the reappearance of pancreatic ß cells. We now show that live donor male or labeled splenocytes administered to diabetic NOD females contain cells that rapidly differentiate into islet and ductal epithelial cells within the pancreas. Treatment with irradiated splenocytes is also followed by islet regeneration, but at a slower rate. The islets generated in both instances are persistent, functional, and apparent in all NOD hosts with permanent disease reversal.
Abstract of this Article
PDF Version of this Article
Supporting Online Material, 百拇医药(生物谷)
Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice
Shohta Kodama, Willem Kühtreiber, Satoshi Fujimura, Elizabeth A. Dale, Denise L. Faustman*
Science, Volume 302, Number 5648, Issue of 14 Nov 2003, pp. 1223-1227
Nonobese diabetic (NOD) mice are a model for type 1 diabetes in humans. Treatment of NOD mice with end-stage disease by injection of donor splenocytes and complete Freund's adjuvant eliminates autoimmunity and permanently restores normoglycemia. The return of endogenous insulin secretion is accompanied by the reappearance of pancreatic ß cells. We now show that live donor male or labeled splenocytes administered to diabetic NOD females contain cells that rapidly differentiate into islet and ductal epithelial cells within the pancreas. Treatment with irradiated splenocytes is also followed by islet regeneration, but at a slower rate. The islets generated in both instances are persistent, functional, and apparent in all NOD hosts with permanent disease reversal.
Abstract of this Article
PDF Version of this Article
Supporting Online Material, 百拇医药(生物谷)