参考文献
http://www.100md.com
中医循证医学
1 WHO.Hepatitis B.Fact Sheet[J].WHO/204.November 1998.
2 Purcell RH.The discovery of the hepatitis virus[J].Gastroenterology 1993:104(4):955-963.
3 Chinese Ministry of Health.Health News[N].Newspaper of Health News22/01 /1999 4th Edition.
4 Liaw YF.Current trends in therapy for chronic viral hepatitis[J].J Gastroenterol and Hepatol 1997;12:S346-S353.
5 B1umberg BS.Hepatitis B virus:search for plant-derived antiviral.In:Tomlinson TR and Akerele D，editors.Medical plants-their role in health and biodiversity[M].Philadelphia:University of Pennsy1vania Press，1998:7.
, http://www.100md.com
6 Calixto JB，Santos ARS，Filbo VC，Yunes RA.A review of the plants of the genus Phyllanthus:their chemistry，pharmacology，and therapeutic Potential[J].Med Res Rev1998;18(4):225-258.
7 Venatewaran PS，Millman I，Blumberg BS.Effects of an extract from Phyllanthus mrurion hepatitis B virus and woodchuck hepatitis viruses:in vitro and in viw studies[J].Proc Natl Acad Sci1987;84:274-278.
8 Chang CW，Lin MT，Lee SS，Liu KC，Hsu FL，Lin JY.Differential inhibition of reverse transcriptase and cellulaLr DNA polymerase-alpha activities by lignans isolated from Chinase herbs，Phyllanthus myrtifolius Moon，and tannins from Lonicera japonica Thunb and Castanopsis hystrix[J].Antiviral Res 1995;27(4):367-374.
, 百拇医药
9 Lee CD，Ott M，Thyagarajan SP，Shafritz DA，Burk RD，Gupta S.Phyllanthus amarus down-regulates hepatitis B virus mRNA transcription and replication[J].Eur J Clin Invest 1996;26(12):1069-1076.
10 Ott M，Thyagarajan SP，Gupta S.Phyllanthus amarus suppresses hepalitis B virus by interrupting interactions between HBV enhancer I and cellular transcription factors[J].Eur J Clin Invest 1997;27:908-915.
11 Blumberg BS，Millman I，Venkateswaran PS，Thyagarajan SP.Hepatitis B virus and primary hepatoce1lular carcinoma:treatment of HBV carriers with Phyllanthusamarus[J].Vaccine 1990; 8(Suppl.):S86-S92.
, 百拇医药
12 Thyagarajan S.P，Jayaram S，Valliammai T,Madanagopalan N，Pal V.G，Jyaraman K.Plyllanthus amarus and hepatitis B[J].Lancet 1990;336 (8720):949-950.
13 Doshi JC，Vaidya AB，Antarkar DS，Deolalikar R，Antani DH.A two-stage clinical trial of Phyllanthus amarus in hepatitis B carriers:failure to eradicate the surface antigen[J].Indian Journal of Gastroenterology 1994;13(1):7-8.
14 Liaw YF，Tsai SL.Pathogenesis and clinical significance of acute exacerbation and remissions in patients with chronic hepatitis B virus infection [J].Viral Hep Rev1997;3:143-154.
, 百拇医药
15 Jadad AR，Moore A，Carroll D，Jenkinson C，Reynolds JM，Gavaghan DJ，et al.Assessing the quality of reports of randomized clinical trials: Is blinding necessary[J]?Control Clin Trials 1996;17(1):1-12.
16 Moher D，Pham B，Jones A，Cook DJ，Jadad AR，Moher M，et al.Does quality of reports of randomised trials affect estimates of intervention efficacy reported in Metaanalyses[J].Lancet 1998; 352:609-613.
17 Kjaergaxd LL，Villumsen J，Gluud C.Quality of randomised clinical trials affects estimates of intervention efficacy (abstract)[C].In: VII Cochrane Colloquium1999，p:57 Rome.
, 百拇医药
18 Clarke M，Oxman AD，editors.Cochrane Reviewers Handbook 4.0; Section 6.In:The Cochrane Library[database on CDROM].The Cochrane Collaboration.Oxford:Update Software;2000，issue 1.
19 Schula KF，Chalmers I，Hayes R，Altman D.Empiricalevidence of bias[J].JAMA 1995; 273(5): 408-412.
20 Vickers A，Goyal N，Harland R，Rees R.De certain countries preduce only positive results? A systematic review of controlled trials[J].Control Clin Trials 1998;19:159-166.
, 百拇医药
21 Egger M，Devey Smith G，Schneider M，Minder C.Bias in Meta-analysis detected by a simple graphical test[J].BwJ 1997;315:629-634.
22 Berk L，de Man RA，Schalm SW，Labadie RP，Heijtink RA.Beneficial effects of Plyllanthus amarus for chronic hepatitis B，not confirmed[letter].Journal of Hepatology 1991; 12(3):405-406.
23 Leelarasamee A，Trakulsomboon S，Maunwongyathi P]，Somanabandhu A，Pidetcha P，Matrakool B，et al.Failure of Phyllanthus amarus to eradicate hepatitis B surfaceantigen from symptomles carriers[J].Lancet 1990;335(8705):1600-1601.
, 百拇医药
24 Milne A.，Hopkirk N，Lucas CR，Waldon J，Foo Y.Failure of New zealand heptitis B carriers to respond to Phyllanthus amarus[J].New zealand Medical Journal1994;107(980):243.
25 彭小昌，刘小莉，刘士昌，杨德珍，王万静，张惠娟。草药叶下珠对HBsAg慢性携带者疗效的初步观察[J]。中华实验和临床病毒学杂志1993；7(3):306-307.
26 Thamlikitkul V，Wasuwat S，Kanchanapee P.Efficacy of Phyllanthus amarus for eradication of hepatitis B virus in chronic carriers[J].J Med Assoc Thai 1991;74(9):381-385.
, 百拇医药
27 Thyagaraan SP，Subramanian S，Thirunalasunddari T，Venkateswaran PS，Blumberg BS.Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus[J].Lancet 1988;2(8614):764-766.
28 Wang MX，Cheng HW，Li YJ，Meng LM，Zhao GL，Mai K.Herbs of the genus Phyllanthus in the treatment of chronic hepatitis B:observations with three preparations from different geographic sites[J].Journal of Laboratory and Clinical Medicine 1995;126(4):350-352.
, http://www.100md.com
29 黄志荣，钟建平，祝桂琅，陈云瑞，王国强。苦味叶下珠治疗乙型肝炎的疗效观察[J]。临床肝胆病杂志1993；9(2):108-110.
30 黄昆明。叶下珠治疗慢性乙型肝炎38例[J]。中医药信息1999；16(6):32.
31 李常青，王新华，李广谦，方宏勋。叶下珠复方治疗慢性乙型肝炎的.临床观察[J]。新中医1998；30(6):45.
32 郑晓瑛，周大桥，高辉，黄彬，周小舟。乙肝3号冲剂治疗慢性乙型病毒性肝炎的临床研究[J]。中国中西医结合脾胃杂志1999；7(1):22-24.
33 曹慰祖，刘家琴，曹登云，苏菲，徐师国[J]。安徽产叶下珠抗乙型肝炎病毒作用的临床研究。中国中药杂志1998；23(3):180-181.
34 马复兴，张芸。复方苦味叶下珠片治疗无症状乙肝病毒携带者临床观察[J]。上海中医药杂志1993；27(5):8-9.
, http://www.100md.com
35 王岭，罗上武，张均倡，董荩，张云。肝康治疗慢性乙型肝炎抗HBV作用研究[J]。中西医结合肝病杂志1999；9(4):14-15.
36 张金良，何文宁，叶萍。苦味叶下珠治疗慢性HBV感染临床观察[J]。中西医结合肝病杂志1992；2(1):8-10.
37 张建军，孙维强，王伯祥。乙肝康特胶囊治疗慢性乙型肝炎69例[J]。中西医结合肝病杂志1996；6( 4):33-34.
38 张建军，孙维强，晏雪生，王伯祥。珍珠草复方胶囊治疗慢性乙型肝炎59例临床观察[J]。实用中西医结合杂志1997；10(9):870-871.
39 李平，黄家莉，徐毅，梁勇。乙肝康特胶囊加胸腺肽治疗慢性乙肝病毒携带者30例[J]。中国中西医结合脾胃杂志1999；7(1):42.
, 百拇医药
40 欧阳亮。胸腺肽联合叶下珠肝片治疗慢性乙型肝炎42例[J]。中西医结合肝病杂志1999；9( 5):44.
41 朱福明，张嘉祺，张孝秩，张锡明。福建产叶下珠对乙肝病毒标志作用的临床观察[J]。中西医结合肝病杂志1992；2(2):10～11.
42 王新华，李常青，郭兴伯，李桦，劳绍祥。叶下珠复方联合干扰素治疗慢性乙型肝炎40例临床观察[J]。中西医结合肝病杂志1999；9(1):12-13.
43 周大桥，郑晓瑛，高辉，周小舟，彭立生，邱梅，等。α干扰素联合乙肝3号浸膏颗粒剂辨治慢性乙型肝炎的研究[J]。中西医结合肝病杂志1999；9(1):5-7., 百拇医药
2 Purcell RH.The discovery of the hepatitis virus[J].Gastroenterology 1993:104(4):955-963.
3 Chinese Ministry of Health.Health News[N].Newspaper of Health News22/01 /1999 4th Edition.
4 Liaw YF.Current trends in therapy for chronic viral hepatitis[J].J Gastroenterol and Hepatol 1997;12:S346-S353.
5 B1umberg BS.Hepatitis B virus:search for plant-derived antiviral.In:Tomlinson TR and Akerele D，editors.Medical plants-their role in health and biodiversity[M].Philadelphia:University of Pennsy1vania Press，1998:7.
, http://www.100md.com
6 Calixto JB，Santos ARS，Filbo VC，Yunes RA.A review of the plants of the genus Phyllanthus:their chemistry，pharmacology，and therapeutic Potential[J].Med Res Rev1998;18(4):225-258.
7 Venatewaran PS，Millman I，Blumberg BS.Effects of an extract from Phyllanthus mrurion hepatitis B virus and woodchuck hepatitis viruses:in vitro and in viw studies[J].Proc Natl Acad Sci1987;84:274-278.
8 Chang CW，Lin MT，Lee SS，Liu KC，Hsu FL，Lin JY.Differential inhibition of reverse transcriptase and cellulaLr DNA polymerase-alpha activities by lignans isolated from Chinase herbs，Phyllanthus myrtifolius Moon，and tannins from Lonicera japonica Thunb and Castanopsis hystrix[J].Antiviral Res 1995;27(4):367-374.
, 百拇医药
9 Lee CD，Ott M，Thyagarajan SP，Shafritz DA，Burk RD，Gupta S.Phyllanthus amarus down-regulates hepatitis B virus mRNA transcription and replication[J].Eur J Clin Invest 1996;26(12):1069-1076.
10 Ott M，Thyagarajan SP，Gupta S.Phyllanthus amarus suppresses hepalitis B virus by interrupting interactions between HBV enhancer I and cellular transcription factors[J].Eur J Clin Invest 1997;27:908-915.
11 Blumberg BS，Millman I，Venkateswaran PS，Thyagarajan SP.Hepatitis B virus and primary hepatoce1lular carcinoma:treatment of HBV carriers with Phyllanthusamarus[J].Vaccine 1990; 8(Suppl.):S86-S92.
, 百拇医药
12 Thyagarajan S.P，Jayaram S，Valliammai T,Madanagopalan N，Pal V.G，Jyaraman K.Plyllanthus amarus and hepatitis B[J].Lancet 1990;336 (8720):949-950.
13 Doshi JC，Vaidya AB，Antarkar DS，Deolalikar R，Antani DH.A two-stage clinical trial of Phyllanthus amarus in hepatitis B carriers:failure to eradicate the surface antigen[J].Indian Journal of Gastroenterology 1994;13(1):7-8.
14 Liaw YF，Tsai SL.Pathogenesis and clinical significance of acute exacerbation and remissions in patients with chronic hepatitis B virus infection [J].Viral Hep Rev1997;3:143-154.
, 百拇医药
15 Jadad AR，Moore A，Carroll D，Jenkinson C，Reynolds JM，Gavaghan DJ，et al.Assessing the quality of reports of randomized clinical trials: Is blinding necessary[J]?Control Clin Trials 1996;17(1):1-12.
16 Moher D，Pham B，Jones A，Cook DJ，Jadad AR，Moher M，et al.Does quality of reports of randomised trials affect estimates of intervention efficacy reported in Metaanalyses[J].Lancet 1998; 352:609-613.
17 Kjaergaxd LL，Villumsen J，Gluud C.Quality of randomised clinical trials affects estimates of intervention efficacy (abstract)[C].In: VII Cochrane Colloquium1999，p:57 Rome.
, 百拇医药
18 Clarke M，Oxman AD，editors.Cochrane Reviewers Handbook 4.0; Section 6.In:The Cochrane Library[database on CDROM].The Cochrane Collaboration.Oxford:Update Software;2000，issue 1.
19 Schula KF，Chalmers I，Hayes R，Altman D.Empiricalevidence of bias[J].JAMA 1995; 273(5): 408-412.
20 Vickers A，Goyal N，Harland R，Rees R.De certain countries preduce only positive results? A systematic review of controlled trials[J].Control Clin Trials 1998;19:159-166.
, 百拇医药
21 Egger M，Devey Smith G，Schneider M，Minder C.Bias in Meta-analysis detected by a simple graphical test[J].BwJ 1997;315:629-634.
22 Berk L，de Man RA，Schalm SW，Labadie RP，Heijtink RA.Beneficial effects of Plyllanthus amarus for chronic hepatitis B，not confirmed[letter].Journal of Hepatology 1991; 12(3):405-406.
23 Leelarasamee A，Trakulsomboon S，Maunwongyathi P]，Somanabandhu A，Pidetcha P，Matrakool B，et al.Failure of Phyllanthus amarus to eradicate hepatitis B surfaceantigen from symptomles carriers[J].Lancet 1990;335(8705):1600-1601.
, 百拇医药
24 Milne A.，Hopkirk N，Lucas CR，Waldon J，Foo Y.Failure of New zealand heptitis B carriers to respond to Phyllanthus amarus[J].New zealand Medical Journal1994;107(980):243.
25 彭小昌，刘小莉，刘士昌，杨德珍，王万静，张惠娟。草药叶下珠对HBsAg慢性携带者疗效的初步观察[J]。中华实验和临床病毒学杂志1993；7(3):306-307.
26 Thamlikitkul V，Wasuwat S，Kanchanapee P.Efficacy of Phyllanthus amarus for eradication of hepatitis B virus in chronic carriers[J].J Med Assoc Thai 1991;74(9):381-385.
, 百拇医药
27 Thyagaraan SP，Subramanian S，Thirunalasunddari T，Venkateswaran PS，Blumberg BS.Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus[J].Lancet 1988;2(8614):764-766.
28 Wang MX，Cheng HW，Li YJ，Meng LM，Zhao GL，Mai K.Herbs of the genus Phyllanthus in the treatment of chronic hepatitis B:observations with three preparations from different geographic sites[J].Journal of Laboratory and Clinical Medicine 1995;126(4):350-352.
, http://www.100md.com
29 黄志荣，钟建平，祝桂琅，陈云瑞，王国强。苦味叶下珠治疗乙型肝炎的疗效观察[J]。临床肝胆病杂志1993；9(2):108-110.
30 黄昆明。叶下珠治疗慢性乙型肝炎38例[J]。中医药信息1999；16(6):32.
31 李常青，王新华，李广谦，方宏勋。叶下珠复方治疗慢性乙型肝炎的.临床观察[J]。新中医1998；30(6):45.
32 郑晓瑛，周大桥，高辉，黄彬，周小舟。乙肝3号冲剂治疗慢性乙型病毒性肝炎的临床研究[J]。中国中西医结合脾胃杂志1999；7(1):22-24.
33 曹慰祖，刘家琴，曹登云，苏菲，徐师国[J]。安徽产叶下珠抗乙型肝炎病毒作用的临床研究。中国中药杂志1998；23(3):180-181.
34 马复兴，张芸。复方苦味叶下珠片治疗无症状乙肝病毒携带者临床观察[J]。上海中医药杂志1993；27(5):8-9.
, http://www.100md.com
35 王岭，罗上武，张均倡，董荩，张云。肝康治疗慢性乙型肝炎抗HBV作用研究[J]。中西医结合肝病杂志1999；9(4):14-15.
36 张金良，何文宁，叶萍。苦味叶下珠治疗慢性HBV感染临床观察[J]。中西医结合肝病杂志1992；2(1):8-10.
37 张建军，孙维强，王伯祥。乙肝康特胶囊治疗慢性乙型肝炎69例[J]。中西医结合肝病杂志1996；6( 4):33-34.
38 张建军，孙维强，晏雪生，王伯祥。珍珠草复方胶囊治疗慢性乙型肝炎59例临床观察[J]。实用中西医结合杂志1997；10(9):870-871.
39 李平，黄家莉，徐毅，梁勇。乙肝康特胶囊加胸腺肽治疗慢性乙肝病毒携带者30例[J]。中国中西医结合脾胃杂志1999；7(1):42.
, 百拇医药
40 欧阳亮。胸腺肽联合叶下珠肝片治疗慢性乙型肝炎42例[J]。中西医结合肝病杂志1999；9( 5):44.
41 朱福明，张嘉祺，张孝秩，张锡明。福建产叶下珠对乙肝病毒标志作用的临床观察[J]。中西医结合肝病杂志1992；2(2):10～11.
42 王新华，李常青，郭兴伯，李桦，劳绍祥。叶下珠复方联合干扰素治疗慢性乙型肝炎40例临床观察[J]。中西医结合肝病杂志1999；9(1):12-13.
43 周大桥，郑晓瑛，高辉，周小舟，彭立生，邱梅，等。α干扰素联合乙肝3号浸膏颗粒剂辨治慢性乙型肝炎的研究[J]。中西医结合肝病杂志1999；9(1):5-7., 百拇医药