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     Ƥ˺ԭס(fibronectin FN)(glucosamino glucoside GAG)ϸ(extracellular matrix ECM)쳣γۻ۸ڴ˹Уϸӣת-(transforming growth factor TGF-)Ƥ(epithelial growth factor EGF)ѪСܻ(platelet derived growth factor PDGF)ΪDZڽʲڻ[1]TGF-ڴϹǹؼӣĿǰоTGF-¼˴ϸ۵γɣҾиӵѧܣӰγɵĸ׶Ρ֢ӦʵĻۼźʵṩˣ˽TGF-γɹеöٴҪ塣

    1 TGF-µ

, http://www.100md.com     ĿǰֵTGF-³Ա40ͬ칹壬ֱࡢС󡢼Ӭܵȣе㷺ܤ[2-3]TGF-¹5칹壬ֱTGF-1-5TGF-1TGF-2TGF-3ڲ鶯У֮60%-80%ͬԴԣTGF-4TGF-5ֱڼܵ֯з֡TGF-1ܴٽƤϸֳֻ̼Ƥϸ˶յFNIJҪáTGF-2ڽϵͳӲƤķҪãTGF-3ƽǻϸDNAϳϱֳԡ

    ԵTGF-Ǿ˫ӵľжܵĶģ112ǵλɣԼΪ25KD塣ÿɺC-ĩ˵390ķǻǰɣʱǰCĩTGF-½ϵɸʷǻ״̬¶ԻѪøʱԵTGF-¼ͷŤ[4]

, Ĵҽҩ     TGF-µϸ棬и߶ȵԺ׺ҪТ񡢢򡢢ͣТ岻ܵTGF-½ϣֻڢTGF-½Ϻγɵĸϣ󽫢GS˿հлữGSТN˼ø߶ȱص򣬼Ģ˿ /հἤøԣԼڵźŴԷӣTGF-ЯźŴݵϸ˲áTGF-1TGF-2и߶ȵ׺ԣĿǰв֪书ܡ

    TGF-һ־жѧЧӦϸӣ֯жԼԹǡΡ̥֯Ϊ࣬ͬʱTGF-¿Աγϸܰϸ/ϸѪСϳɲͷţڴʱЩϸΪDZڵTGF-Դ˺֯޸УиŨTGF-µѪС˲λͨѿʽͷTGF-¤[5]֮TGF-˿ϵĸӵл̡TGF-µյܺյECMĹܣԲ۵γҪTGF-´̼FNڵĶϸʳҪΪ쵰סԭ͵׶Ǥ[6]ͬʱͨ͵øĺϳɼߵøƼˮƽֹECM⡣TGF-¿صıﲢͨıϸĤϵԱʹԻճ[7]Щ޸ȻTGF-յϸʹֳɵ²ۺά
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    2 TGF-봴޸γ

    ֯޸һܸӵḶ́漰ϸECM໥ãTGF-໥õҪӣʵ֤TGF-¶ƤϸãܹٽƤϸֳӽǻϸ˶ͨPDGFüӴ̼Ƥϸ̼γϸĽǵ׵ı蘭[8]

    TGF-¶ԻʵҪڴ̼άϸ백ת˺ǽͽĽУECMϳӤ[9]ԭάճסǵסǺ͸ȡͬʱͨƻʽøIJٽøIJǿϸĽϣ˿Ӻ;ֲάСƤעԴԵTGF-¿յάѪγɤ[6]Ƥ֯עTGF-1ڸɴˣ˺7췢ָôдϸͳάϸԵĽԭעˮδϸĽͳάϸۼԭ΢ڼõȫƤȱʧIJλֲTGF-1Ľԭ֧Ҳɹ۲쵽˿Ƥӿ줟[10]ûTGF-1̼˽ԭFnӣʹת¼ӣǿԭӻɸӢ񴫵ݵģӶ½ԭϳӺͼٽԭij줟[11]
, Ĵҽҩ
    ĿǰȻTGF-֯޸˽⣬ֹϹ̻۹γȴ֪֮٣ͨ˺ͶоTGF-˿ϣTGF-µĹȴпܵۺάγɡΡάо֣TGF-¿͵ϸߢͺ͢ǰԭmRNAıƲTGF-άпҪä[12]ͬʱTGF-˺йȱ̶ȳȤ[13]йTGF-¶ijάϸ(fribroblast FB)лӰоTGF-۵γɣֱӻӼʵ׵ĺϳڣٽԭʵճĻǶ෽ģTGF-´ٽάϸϳɢ񡢢ͽԭ׺FNTGF-Ӣ񡢢ͽԭFNmRNAˮƽֱӴ̼񡢢ͽԭӺFNĻԣܽ͵øĺϳɺͷڣƽԭøĻԣECMĽ⣻ϸECM໥ãߴٽFNͽԭʵճ
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    ֪̥ڡƤ޸ͨ֯γƤṹɣϵĻв[1]LinȽ̥ƤֲƤ£˿ڳϣڳƤֲģУ˿ڴγɣͬʱóƤ̥ƤԼTGF-»ƬƤ£ͬʱȡ˿ڴƤֱԭλӽ黯ȾɫʾƤյTGF- mRNAı̥ƤģУδTGF- mRNAıԴTGF-Ƥʱɹ۲쵽ǰԭǿڳ֢ӦԼγɣɼTGF-γҪá

    3 ת-¼ת-µٴӦǰ

    3.1 TGF-12ٽϣĿǰTGF-ٴҪϵ˿ڻƤˣϵĴɴлҡϡѪԼѹƻģԴTGF-ܴٽʵ鶯иˡг˺˵ȵϣԸƤʼغͷϲһЩƫĶ˿ͣԴTGF-»϶˿Ϥ[14]˿ڵĴкдĵøǰȱЧƼЩøĻԣʹЧĴҩ;ҲʹڰϸҩﵽЧŨȶáѾ谭ٴӦõһ⣬ԽоֲʹTGF-µص̽Чҩ;
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    3.2 ԤۣTGF-µѧãϿɼ۵γɣTGF-µ;ܶ࣬TGF-µĻTGF-1ϸĽϡ

    3.2.1 ãTGF-γɵо֣ӦÿTGF-¿ܻۣShah[15]ڳƤ¾ֲעTGF-1TGF-2ɽTGF-µˮƽٵϸϸFNIͽԭijγ٣ȣ˲λƤƤṹӽעTGF-෴ĽڴڣӦTGF-¿ԼTGF-ˮƽTGF- mRNAյƾϸTGF-µͷŸҪá

    3.2.2 TGF-3ãٴӦTGF-кͿ壬ԭԵӰƣTGF-µصĹܡTGF-3ܽTGF-1TGF-2ӶʾTGF-3ɳΪӣShah[16]ӦTGF-3˿ע䣬70˿Լ١
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    3.2.3 ׿Ӧ6-¶ܹ϶TGF-мõȵ-(insulin growth factor-II IGF-II)6-¶壬۵ɡĵ׾(decorin)TGF-徺ԽϣTGF-»ԵСӵ׶ǣڴעdecorinɷֹECMTGF-µIJ뿹TGF-¿ȣdecorinȻڵʣҲԭԣи㷺Ӧǰ⣬÷ѺTGF-»ÿTGF-Һϴ˿ڣTGF-µĽλ㣬ҲɴﵽһĿ۵Ч

    ЩĹ㷺ٴӦûѣѧεʱѡ񡢷ʽѡ񡢼ѡ񡢳ЧȷͳһʶTGF-µоչΪ˿Ϲ۵γṩ˼·ͷFBijЩӻӶTGF-µĴ̼TGF-¶ECMϳɵĴ̼ԼTGF-׿ȣ֮TGF-µƼڷۺͿάһǴпΪġ
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    [ο]

    [1] Lin RY,Sullivan KM,Argenta PA,et al.Exogenous transforming growth factor amplifies its own expression and induces scar formation in a model of human fetal skin repair[J].Ann Surg,1995,222(2):146154.

    2 Kingsley DM.The TGF- superfamilynew membersnew receptors and new genetic tests of function in different organisms[J].Genes Dev,1994,8(2):133146.

    3 Massague J.TGF-beta signal transduction[J].Annu Rev Biochem,1998,67:753791.
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    4 Lyons RM,Keski-oja J.Moses HL.Proteolytic activation of latent transforming growth factor-beta from fibroblas-conditioned medium[J].J Biol Chem,1988,106(5):16591665.

    5 Assoian RK,Sporn MB.Type transforming growth factor in human plateletsrelease during platelet degranulation and action on vascular smooth muscle cells[J].J Cell Biol,1980,102:12171223.

    6 Roberts AB,Sporn MB,Assoian RK,et al.Transforming growth factor ¦rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro[J].Proc Natl Acad Sci USA,1986, 83(12): 41674171
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    7 Ignotz RA,Massague J.Cell adhesion protein receptors as targets for transforming growth factor- action[J].Cell1987,51(2):189197.

    8 Frank S,Madlener M,Werner S.Transforming growth factor beta1beta2 and beta3 and their receptors and differentially regulated during normal and impaired wound healing[J].J Biol Chem,1996,271(17):1018810193.

    9 Mcmullen H,Longaker MT,Cabrera RC,et alSpatial and temporal expression of transforming growth factor- isoforms during ovine excisional and incisional wound repair[J].Wound Rep Reg,1995,3[1]:141156.
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    10 Krummel TM,Michna BA,Thomas BL,et al.Transforming growth factor £TGF-£ induces fibrosis in a fetal wound model[J].J Pediatr Surg,1988,23(7):647652.

    11 Pierce GF,Berg JV,Rudolph R,et al.Platelet-derived growth factor-BB and transforming growth factor beta-1 selectively modulate glycosaminoglycanscollagen myofibroblasts in excisional wounds[J].Am J Pathol,1991,138(3):629646.

    12 Rossert J,Terraz Durasnel C. Brideau G.Growth factors cytokines and renal fibrosis during the course of diabetic nephropathy[J].Diabetes Metab,2000,26Suppl:41624
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    13 Zhang K,Garner W,Cohen L,et al.Increased types andcollagen and transforming growth factor-beta 1 mRNA and protein in hypertorphic burn scar[J].J Invest Dermatol,1995,104(5):750754.

    14 Sporn MB,Roberts AB,A major advance in the use of growth factors to enhance wound healing[J] .J Clin Invest,1993,92(6):25652566.

    15 Shah M,Foreman DM,Furguson MW.Control of scarring in adult wounds of neutralising antibody to transforming growth factor tabe[J]. Lancet,1992,339(8787):213214.

    16 Shah M,Foreman DM,Furguson MW.Neutralisation of TGF beta 1 and TGF beta 2 or addition of TGF beta 3 to cutaneous rat wounds reduces scarring [J].J cell Sci,1995,108(Pt 3):9851002., Ĵҽҩ