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编号:10532817
诱导型一氧化氮合酶与疾病
http://www.100md.com 2004年8月15日
     陈慎仁 陈林兴 陈少如 2004-8-1 17:20:01 中国病理生理杂志 2000年第2期第16卷 综述

    Inducible nitric oxide synthase in diseases

    CHEN Shen-ren, CHEN lin-xin

    (The 2nd Clinical School in Medical College of Shantou University,Shantou 515041)

    CHEN Shao-ru(Pathophysiology of Medical College, Shantou University, Shantou 515031, China)

    【A Review】 Nitric oxide(NO) is a biologically active molecule in vivo,it has been found to play an important role not only as a cytotoxic effector but also an immune regulatory mediator and a signal molecule of message transmission.The inducible NO synthase (iNOS) produces NO after cells were activated and play a rather complicated pathophysiological action in a variety of human diseases or disorders. The molecular biological character of iNOS,its expression in human diseases and probable significance were reviewed.

    [MeSH] Nitric Oxide; Disease

    迟至20世纪80年代末,一氧化氮(nitric oxide, NO)才被认识到是人体内一种生物学活性分子。人体内的NO有两个来源。一为非酶生(non-enzymstigenese),来自体表或者摄入的无机氮的化学降解/转化;一为酶生(enzymstigenese),由NO合酶(NO synthase NOS)所合成。现已认识到NO既是一个有细胞毒性效应器作用的分子,是组织损伤的诱发因子和各种病变的增强因子,有其病理上不好的一面;又是生物体许多部分的信号(signal)分子 ......

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