肖贞良 孙耕耘 2004-8-2 20:09:56 生理科学进展1998年第29卷第3期

    摘要 血管内皮屏障功能的调节机制相当复杂。α-凝血酶等炎症性介质引起内皮通透性增高的机制可能是通过G蛋白激活磷脂酶，介导三磷酸肌醇等第二信使产生，并进一步激活蛋白激酶C和肌球蛋白轻链激酶，最终引起球蛋白轻链磷酸化，从而导致内皮细胞F-肌动蛋白骨架重排，中心张力增加，细胞间裂隙形成，内皮细胞通透性发生改变。

    Research Progress on Regulation of Vascular endothelial Barrier Function

    XIAO Zhen-Liang,SUN Geng-Yun(Institute of Respiratory diseases,Xinqiao Hospital,Third Military Medical University,Chongqing 400037)

    Abstract The regulatory mechanisms of vascular endothelial barrier function are complicated.Inflammatory mediators,such as-α-thrombin,activate phospholipases to mediate generation of IP3 ans other second messsengers through receptor-coupled G protein.Protein kinase C and myosin light chain kinase are then activated,leading to phosphorylation of myosin light chains,rearrangement of F-actin skeleton,interendothelial cell gap formation and increased endothelial permeability.

    Key words Barrier function;Endothelium;Permeablity;Regulation

    血管内皮包括内皮细胞(EC)单层和基膜，是血管腔面的一层半选择性通透屏障。血管内外溶质和液体的交换受体内皮通透性大小控制。通透性是检测内皮屏障功能的客观计量指标。许多炎性、成血栓性(thrombogenic)介质均可损伤内皮屏障功能，导致其通透性增高 ......