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醒脑静注射液对急性脑出血患者血中细胞因子水平影响的研究
http://www.100md.com 2004年11月17日 中国中西医结合急救杂志2004年7月第11卷第4期
     陈 坚,张素平,徐武华,王慕真,梁瑞华

    (广州市红十字会医院,广东 广州 510220)

    【摘要】 目的:观察醒脑静注射液对急性脑出血患者外周血中炎症细胞因子水平的影响。方法:将70例急性脑出血患者随机分为醒脑静注射液治疗组和胞二磷胆碱注射液对照组,每组35例。采用放射免疫法测定各组患者治疗前后血中肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、IL-6水平,并与20例正常人进行对照。结果:两组急性脑出血患者血浆TNF-α、IL-1、IL-6的水平均明显高于正常对照组(P均<0.05)。使用醒脑静注射液治疗后,血浆TNF-α、IL-1水平均明显下降,下降程度也明显高于胞二磷胆碱治疗对照组(P均<0.05);IL-6的水平虽有下降,但两治疗组间无显著差异。结论:醒脑静注射液较胞二磷胆碱更能显著抑制炎症细胞因子的释放,降低细胞因子的水平。

    【关键词】 脑出血,急性;肿瘤坏死因子;白细胞介素;中医药治疗

    Effect of Xingnaojing injection(醒脑静注射液) on the serum levels of cytokines in patients with acute intracerebral hemorrhage

    CHEN Jian, ZHANG Su-ping, XU Wu-hua, WANG Mu-zhen, LIANG Rui-hua.

    Department of Neurology, Guangzhou Red Cross Hospital, Guangzhou 510220, Guangdong, China

    【Abstract】 Objective: To investigate the therapeutic effects of Xingnaojing injection(醒脑静注射液) on serum levels of inflammatory cytokines in acute intracerebral hemorrhagic patients. Methods: Seventy patients were randomly divided into two groups: the Xingnaojing injection treatment group (treatment group, n=35) and the citicoline injection treatment group (control group, n=35). Tumor necrosis factor-α(TNF-α), interleukin-1(IL-1) and IL-6 were analyzed by radioimmunoassay before and after the treatment. Twenty healthy people were as normal control. Results: The serum levels of TNF-α, IL-1, IL-6 in both treatment groups were higher than those of normal control group(all P<0.05). Xingnaojing injection could decreased TNF-α and IL-1 levels significantly, and the decreasing extent was greater than that of the citicoline treatment group(all P<0.05). Both Xingnaojing and citicoline treatment could decrease the serum level of IL-6, but there was not any difference between the two groups. Conclusion: Xingnaojing injection can inhibit releasing of inflammatory cytokinesand decrease cytokines levels more effectively than citicoline. ......

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