西安医科大学第一临床医学院肝炎研究室 陕西省西安市 710061

    蔺淑梅，女，1963-11-09生，陕西省华县人，汉族.医学硕士，主治医师，从事病毒性肝炎发病机理与防治研究10年，发表学术论文8篇，国外文献综述3篇，译文摘要10篇

    项目负责人 蔺淑梅,710061 西安市健康路1号 ,陕西省西安市,西安医科大学第一临床医学院肝炎研究室

    Tel: 029- 5263596-416收搞日期 1995-07-18

    The significance of recombinant immunoblot assay in acute hepatitis C

    Shu-Mei Lin, Shu-Lin Zhang,Peng-Chao Di and Xue-Song Liang

    Hepatitis Laboratory, First Clinical College, Xi'an Medical University, Xi'an 710061 Shanxi Province, China

    Abstract

    AIMS To study the significance of RIBA in diagnosis of acute hepatitis C.

    METHODS RIBA including three recombinant HCV antigen (C₂₂, C_33c,C_100-3) was developed in our laboratory, and serum samples from 20 patients with acute hepatitis C were investigated. The results of RIBA were compared with the results of RIA-2(second generation radioimmunoassay for anti-HCV).

    RESULTS RIBA positive rate was much higher than that of RIA-2 either within one month or by the third month after disease onset(85% vs 40%, P <0.05 and 100% vs 70%, P <0.05); The positive rate of anti-C₂₂ and anti-C_33C(90% and 80% respectively within one month after disease onset, by the third month reaching 100%) was much higher than that of anti-C_100-3 (45% within one month and 70% by the third month). ......