Circulating soluble intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in patients with gastric cancer
Circulatingsolubleintercellularadhesionmolecule-1andvascularcelladhesionmolecule-1inpatientswithgastriccancer,Correspondenceto,Abstract,,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,INTRODUCTION,MATERIALSANDMETHODS,Methods,Statisticalanalysis,RESUL
Shanghai First Peoples Hospital, Shanghai 200080, ChinaDr. Yu-Fa Wang, male, born on 1963-07-31 in Shanghai, graduated from Shanghai Medical University in 1987 and got master degree from Shanghai Institute of Immunology, Shanghai Second Medical University in 1990, now associated professor,having 20 papers published.
Correspondence to Dr. WANG Yu-Fa, Central Research Laboratory, Shanghai First Peoples Hospital,85 Wujin Road, Shanghai 200080, China
Tel. +86·21·63240090 ext 4602
Reveived 1998-07-15
Abstract
AIM To elucidate the biological and clinical significance of sICAM-1 and sVCAM-1 in patients with gastric cancer.
METHODS The serum levels of soluble ICAM-1 and VCAM-1 were measured with sandwith enzyme immunoassay.
RESULTS In gastric cancer patients, soluble ICAM-1 and VCAM-1 concentrations were significantly elevated in comparision with those of healthy subjects (289.23μg/L±32.69μg/Lvs 190.44μ/L±35.92μg/L，1430.88μg/L±421.71μg/L vs 727.24μg/L±157.68μg/L, respectively, P<0.01). The increment in serum sICAM-1 and sVCAM-1 concentrations correlated well with the staging of gastric cancer. The serum levels of sICAM-1 and sVCAM-1 in patients of Ⅲ-Ⅳ stages were higher than those of Ⅰ-Ⅱ stages (346.60μg/L±92.10μg/Lvs257.54μg/L±32.77μg/L, 1800.60μg/L±510.76μg/L vs 1262.81μg/L±236.73μg/L). The levels of sICAM-1 and sVCAM-1 were correlated significantly (r=0.49 ......
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