一氧化氮和自由基对大鼠急性肝损伤的作用
硫代乙酰胺;肝损伤;一氧化氮;自由基,项目负责人,Correspondenceto,Effectofnitricoxideandfree,radicalsonacuteliverinjuryinrats,Abstract,,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘要,目的,方法,结果,结论,主题
山西医科大学 1第二医院消化内科 2第一医院干部科 太原市 030001滕书玲，女，1936-07-03生，辽宁省沈阳市人，汉族. 1960年山西医科大学医疗系毕业，教授、主任医师，主要从事肝肠病诊治和研究，发表论文26篇.
项目负责人 滕书玲，030001，山西医科大学第二医院消化内科，山西省太原市五一路382号.
Correspondence to Shu-Ling Teng, Department of Gastroenterology, The Second Affiliated Hospital, Shanxi Medical University, 382 Wuyilu, Taiyuan 030001, Shanxi Province, China
Tel. +86·351·3074231 Ext. 2352
收稿日期 1998-06-29
Effect of nitric oxide and free radicals on acute liver injury in rats
Shu-Ling Teng, Xi-Run Wu and LingXi
1Department of Gastroenterology, The Second Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
2Department of , The First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Abstract
AIM To observe the formation and effects of nitric oxide (NO) and free radicals on acute liver injury induced by thioacetamide (TAA).
METHODS ①Twenty-four rats randomly divided into four groups. One was normal, another three were hepatic injury. The animals of injury groups were injected one single dose of TAA 600mg/kg sc. the blood content of endotoxin and NO3-/NO2-, ALT, ALT and AST at 24, 48 and 72 hours were measured. The protein content, activity of SOD and GSHpX were measured in liver homogenate. Meanwhile the liver morpho-pathology was examined. ②Thirty-two rats were drvided into four groups, group A was normal, the other animals were given TAA 600mg/kg sc. in groups B, C and D, with acute liver injury. The rats of group B were given normal saline 0.4mL/kg; group C, 7.5% L-Arg (300mg/kg); group D, 2.5% L-NNA (10mg/kg), once again after 24 hours. Then according to the first experiment, the blood and liver tissue were obtained assaied for the same times. ......
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