肝内血管病变与肝炎病变关系的研究
肝炎;肝硬变;肝血管病变,项目负责人,Correspondenceto,Studyontherelationshipbetweenintrahepaticvasculardiseasesandhepatitis,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,,摘要,目的,结果,结论,主题词,0引言
中国人民解放军123医院病理科 安徽省蚌埠市 233015严家春，男，1941-06-26生，安徽省定远县人，汉族. 1972年第七军医大学医资班毕业，主任医师，教授，主要从事肝脏的病理研究，发表论文125篇. 获军队科技进步二、三、四等奖14项.
项目负责人 严家春，233015，安徽省蚌埠市，中国人民解放军123医院病理科.
Correspondence to Jia-Chun Yan, Department of Pathology, Chinese PLA 123 Hospital, Bengbu 233015, Anhui Province, China
Tel. +86·552·4125701(H)
收稿日期 1999-05-11 接收日期 1999-07-11
Study on the relationship between intrahepatic vascular diseases and hepatitis
Jia-Chun Yan, Yong Ma, Wen-Bi Chen and Jian-Hu Liu
Department of Pathology, Chinese PLA 123 Hospital, Bengbu 233015, Anhui Province, China
Abstract
AIM To study the relationship between intrahepatic vascular diseases and liver injury.
METHODS Two thousand liver specimens of hepatic diseases were studied with HE, histochemistry, immunohistochemistry and electron microscopy.
RESULTS Intrahepatic vascular inflammation, damage and obstruction increased with the enhancement of hepatic necrosis in acute hepatitis (P<0.01), while in chronic hepatitis, intrahepatic vascular inflammation, damage, obstruction and proliferation changed gradiently with the severity of hepatic diseases (P<0.01). And in liver cirrhosis, intrahepatic vascular proliferation and fibrosis were significant, which was related with the size of node and the width of fibrous zone (P<0.01), and elastic fibrosis. Immunohistochemistry showed that α-SMA was strongly positively expressed in fibrous zones, vascular endotheliocyte and myofibroblast. Electron microscope showed that vascular endotheliocyte germinated and formed a tubular structure. ......
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