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人乳头状瘤病毒HPV-E6及P53蛋白与食管鳞癌关系
http://www.100md.com 2000年5月15日 《世界华人消化杂志》 2000年第5期
食管肿瘤;癌;鳞状细胞;P53蛋白;人乳头状瘤病毒,项目负责人,Correspondenceto,RelationshipbetweenHPV-E6P53proteinandesophagealsquamouscellcarcinoma,,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘
     中国人民解放军第四军医大学唐都医院病理科 陕西省西安市 710038

    刘节,男,1964-06-01生, 江苏省徐州市人,汉族. 1996年中国人民解放军第四军医大学实验技术本科班毕业,现为第四军医大学病理专业硕士研究生,主要从事于消化道肿瘤发生机制的研究,发表论文16篇.

    项目负责人
刘节,710038,陕西省西安市,中国人民解放军第四军医大学唐都医院病理科.

    Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China

    Correspondence to
Jie Liu, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China

    Tel. 0086-29-3577744

    Email. Liujiec@fmmu.edu.cn

    收稿日期 1999-12-12 接收日期 2000-01-28

    Relationship between HPV-E6 P53 protein and esophageal squamous cell carcinoma

    Jie Liu, Qin Su and Wei Zhang

    Abstract

    AIM To investigate the mechanisms of esophageal carcinogenesis by HPV-E6 infection in esophagus as well as expression

    of P53 protein.

    METHODS HPV-E6 and P53 protein was examined by immunohistochemical method in 116 paraffin-embedded cases of different esophageal tissues.

    RESULTS HPV-E6 infection rate in normal mucosa, inflammatory mucosa, moderate or severe dysplasia and esophageal carcinoma tissues were 37%, 39%. 50% and 73%, at the same time, nuclear P53 protein positive were 0%, 6%, 41% and 63%. Besides, the expression of HPV-E6 and P53 protein in 60 carcinomas is closely associated with the pathohistological grading and HPV-E6 infection with the positive expression of P53 in carcinoma tissues was significantly higher than HPV-E6 negative with the positive expression of P53 statistically. ......

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