Heme Oxygenase-1对乙酸诱导大鼠胃溃疡的保护作用
血红蛋白氧化酶-1;乙酸;大鼠;胃溃疡;诱导型一氧化氮合酶;免疫组织化学,HemeOxygenase-1对乙酸诱导大鼠胃溃疡的保护作用,项目负责人,Correspondenceto,Protectiveeffectofhemeoxygenase-1onaceticacidinducedgastriculcerinrats,,Abstract,AIM,METHODS,RESULTS,2
上海医科大学附属中山医院消化科 上海市 200032沈锡中，男，1963-01-18生,江苏省启东市人，汉族. 1982年南通医学院毕业，1989年安徽医科大学医学硕士，1995年上海第二医科大学医学博士. 现为上海医科大学附属中山医院消化科副主任，副教授. 主要从事胃肠病基础和临床，发表论文20篇.
项目负责人 沈锡中，200032，上海市医学院路136号，上海医科大学附属中山医院消化科.
Department of Gastroenterology, Zhongshan Hospital, Shanghai Medical University, Shanghai 200032, China
Correspondence to Dr. Xi-Zhong Shen, Department of Gastroenterology, Zhongshan Hospital, Shanghai Medical University,136 Yixueyuan Road, Shanghai 200032, China
Tel. 0086-21-64041990 Ext.2070
Email. shenxz99@yahoo.com
收稿日期 2000-05-12 接收日期 2000-05-16
Protective effect of heme oxygenase-1 on acetic acid induced gastric ulcer in rats
Xi Zhong Shen
Abstract
AIM To investigate the possible role of heme oxygenase-1 (HO-1) in acetic acid induced gastric ulcer in rats.
METHODS HO-1 and inducible nitric oxide synthase(iNOS) mRNA and protein were determined at different time points after acetic acid induced gastric ulcer in rats by RT-PCR and western blotting, respectively. The severity of ulcer was assessed by ulcer area. Tin mesoporphyrin(SnMP) was used to inhibit the activity of HO. ......
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