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二乙基亚硝胺诱发大鼠肝细胞癌发生过程中基质金属蛋白酶动态变化
http://www.100md.com 2001年7月15日 《世界华人消化杂志》 2001年第7期
癌,肝细胞,病理学;基质金属蛋白酶,分析;二乙基亚硝胺,药理学;疾病模型,动物;肝肿瘤,实验性,病理学,项目负责人,Dynamicchangesofmatrixmetalloproteinasesinlivertissueduringthedevelopmentofdiethylnitrosam
     中国人民解放军第一军医大学珠江医院肝胆外科 广东省广州市 510515

    蒋泽生,男,1972-02-21生,河南省潢川县人,汉族,1995年第一军医大学临床医学系毕业,现为第一军医大学珠江医院肝胆外科硕士研究生,主要从事肝癌转移方面的研究,发表论文4篇.

    广东省自然科学基金博士启动基金,No. 974053

    项目负责人 高毅, 510515, 广州市工业大道253号, 中国人民解放军第一军医大学珠江医院肝胆外科.

    Dynamic changes of matrix metalloproteinases in liver tissue during the development of diethylnitrosamine-induced rat hepatocarcinoma

    
Ze Sheng Jiang, Shi Gang Fang, Yi Gao, Shuang Wang and Jian Feng Chen

    Department of Hepato-Biliary Surgery, Zhujiang Hospital, The First Military Medical University, Guangzhou 510515, Guangdong Province, China

    Correspondence to: Ze Sheng Jiang, Department of Hepato-Biliary Surgery, Zhujiang Hospital, 253 Industry Road, Guangzhou 510515, Guangdong Province, ChinaTel 0086-20-85143557Email. jzsdxx@263.net

    Received 2000-11-15 Accepted 2000-11-16

    Abstract

    AIM
To study the dynamic changes of the latent and activated forms of MMP-2 and MMP-9 in rat liver tissue during experimental hepatocarcin ogenesis.

    METHODS Hepatocellular carcinomas were induced with the adminis tration of diethy lnitrosoamine (DENA) in rats. Gelatin zymography was used for the detection of latent and activated forms of MMP-2 a nd MMP-9 in six phases of three carcinogenic successive stages, these are, the non-specific changes reacting to the drug toxicity, the precancerous lesions and the lesions of hepatocellular carcinoma. ......

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