中国人民解放军第二军医大学长海医院病理科 上海市 200433

    倪灿荣，男，高级实验师，上海市病理学会委员，主要从事病理技术，发表各类论文106篇，主编《免疫组织化学实验技术及应用》1部，参编专著3部.

    项目负责人 倪灿荣，200433，上海市，中国人民解放军第二军医大学长海医院病理科.

    Tel: 0086-21-25070279

    收稿日期2001-03-02接受日期2001-06-15

    Expression significance of GST-π, P-gp, Top-Ⅱ and nm23H1 in gastric carcinoma

    Can Rong NiDepartment of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

    Correspondence to Can-Rong Ni, Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

    Tel: 0086-21-25070279

    Received 2001-03-02 Accepted 2001-06-15

    

    Abstract

    AIM To study the relationship of the GST-π and the biological behavior, the expression of P-gp, Top-Ⅱ and nm23H1 in gastric carcinoma.

    

    METHODS GST-π, P-glycoprotein, Top-Ⅱ and nm23H1 were detected in 66 cases of the primary gastric carcinoma using immuno histochemical catalyzed signal amplification.

    

    RESULTS The positive rates of GST-π, P-glyco protein, Top-Ⅱ and nm23H1 were 82%, 77%, 50% and 58% respectively. Significant relationships were found between GST-π or Top-Ⅱ expression and histological type of gastric carcinoma (χ²=6.45 and χ²=5, P<0.05). There was a positive correlation between GST-π expression and lymph node metastasis (χ ²=10.048, P<0.01) and a reverse co rrelation between nm23 expression and lymph node metastasis. The progression of gastricarcinoma was correlated with the high expression of GST-π, P-glycoprotein and nm23H1. The high GST-π and P-glycoprotein expression was correlated with the survival of less than three years(χ²=9.506, P<0.01 and χ²=8.439, P<0.01), but high expression of nm23 was correlated with a survival of more than three years (χ²=10.89, P<0.01). ......