梅俏，于皆平， 武汉大学人民医院消化内科 湖北省武汉市 430060

    许建明，项立，安徽医科大学第一附属医院消化内科 安徽省合肥市 230032

    梅俏，男，1971-05-12生，安徽省太湖县人，汉族.1996年安徽医科大学硕士毕业，现为武汉大学人民医院消化内科博士研究生，主要从事消化道疾病药物防治方面的研究.

    项目负责人 于皆平，430060，湖北省武汉市武汉大学人民医院消化 内科. meiqiao@hotmail.com

    收稿日期 2001-11-15 接受日期 2001-11-27

    The effects of melatonin on the immunological function of coliti s in rats

    Qiao Mei，Jie-Ping Yu，Jian-Ming Xu，Li Xiang

    Qiao Mei,Jie-Ping Yu,Department of Digestion, Renmin Hospital of Wu han University, Wuhan 430060, Hubei Province, China

    Jian-Ming Xu, Li Xiang, Department of Digestion, The First Affiliated Hospital of Anhui Medical University, Hefei 230032,Anhui Province, China

    Correspondence to: Prof. Jie-Ping Yu, Department of Digestion, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.

    Received 2001-11-15 Accepted 2001-11-27

    

    Abstract

    AIM:To investigate the effects of melatonin on the immunologi cal function of rats with immunological colitis.

    METHODS:The immunological colitis model of rats was produced by intracolon enema with trinitrobenzene sulfonic acid(TNBS) and ethanol. The exper iment animals were divided into 6 groups: normal group,model group,5-ASA group( 100mg·kg^-1),MT groups(2.5 ......