HBV转基因小鼠免疫耐受机制的实验研究
项目负责人,MechanismofimmunetolerancewithchronichepatitisBvirusinfectioninhepatitisBvirustransgenicmice,Correspondenceto:,Abstract,AIM:,METHODS:,RESULTS:,CONCLUSION:,摘要,目的:,方法:,结果:,结论:,0,引言,1,材料和方法,1.1材料
熊一力，刘光泽，贾彦征，中国人民解放军第458医院全军传染病中心 广州市 510602熊一力，女，1954-04-18生，四川省通江县人，汉族，1997年博士后第二站出站，主任医师，主要从事慢性乙型肝炎治疗及转基因动物模型制备研究.
项目负责人 熊一力, 510602，广州市东风东路801号，中国人民解放军第458医院全军传染病中心. xyili@163.net
电话: 020-87373156
收稿日期 2002-01-11 接受日期 2002-03-05
Mechanism of immune tolerance with chronic hepatitis B virus infection in hepatitis B virus transgenic mice
Yi-Li Xiong, Guang-Ze Liu, Yan-Zheng Jia
Yi-Li Xiong, Guang-Ze Liu, Yan-Zheng Jia，PLA Infection Disease Center, Guangzhou 510602，Guangdong Province, China
Correspondence to: Yi-Li Xiong, PLA Infection Disease Center, 801 Dongfeng East Road, Gangzhou 510602, China. Xyili@163.net
Received 2002-01-11 Accepted 2002-03-05
Abstract
AIM:To investigate the antigen-presenting function of dendritic cell (DC), the immune states of T lymphocytes (TC) and hepatocytes (HC) in hepatitis B virus (HBV) transgenic mice (HBV-Tg) as an animal model of chronic HBV infection, and to probe into the mechanism of immune tolerance.
METHODS:Expression levels of spleen DC, TC and HC surface molecules, the proliferation response to HBsAg stimulation and the amounts of cytokines on TC in HBV-Tg were measured by flow cytometry,3H-thymidine incorporation, enzyme linked immunoabsorbent assay and immunohistochemistry, respectively. ......
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