张燕敏，邓长生，朱尤庆，张可，杨院平，武汉大学医学院中南医院消化内科 湖北省武汉市 430071

    毛永荣，湖北肿瘤医院病理科 湖北省武汉市 430072

    张燕敏, 女,1976-10-26生, 湖北省武汉市人, 汉族. 1994年湖北医科大学医疗系本科毕业, 现为武汉大学中南医院消化内科硕士研究生.

    项目负责人 张燕敏, 430071，湖北省武汉市，武汉大学中南医院消化内科 yanminz@sina.com

    收稿日期 2001-12-19 接受日期 2002-03-18

    Correlation between expression of hypoxia-inducible factor-1αmRNA and angiogenesis in gastric adenocarcinoma

    Yan-Min Zhang，Chang-Sheng Deng,You-Qing Zhu，Yong-Rong Mao, Ke Zhang, Yuan-Pin Yang

    Yong-Rong Mao, Department of Pathology, Hubei Cancer Hospital, Wuhan 420072, China

    Correspondence to: Zhang Yanmin, Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China. yanminz@sina.com

    Received 2001-12-19 Accepted 2002-03-18

    Abstract

    AIM:To investigate the expression of hypoxia-inducible factor-1α(HIF-1α)mRNA and vascular endothelial cell growth factor(VEGF)in gastric adenocarcinoma and its relation with the microvessel density (MVD), and to analyze their the significance in clinical research.

    METHODS:Expression of HIF-1mRNA was detected by in situ hybridization, and the expression of VEGF protein and microvessel density was studied by immunohistochemical methods. ......