p16抑癌基因CpG岛甲基化
董科，李波，,覃杨，李承志，孙芝琳，孙泽芳，,董科，,项目负责人,MethylationpatternanalysisinCpGislandsofp15andp16tumorsuppressorgenesinpancreaticcarcinomatissue,Correspondenceto:,Received,Accepted,Abstract,摘要,目的:,方法:,结果:,结论:,0引
董科，李波，四川大学华西医院普外科二，四川省成都市 610041覃杨，李承志，孙芝琳，孙泽芳，四川大学基础医学院分子生物学实验室 四川省成都市 610041
董科，男，34岁，重庆人，四川大学华西医院普外科在读博士.
项目负责人 董科，610041,四川省成都市,四川大学华西医院普外二.
电话:028-85422476
收稿日期 2002-07-01 接受日期 2002-07-30
Methylation pattern analysis in CpG islands of p15 and p16 tumor suppressor genes in pancreatic carcinoma tissue
Ke Dong, Bo Li, Yang Qin, Cheng-Zhi Li, Jian-Yu Liu Zhi-Lin Sun, Ze-Fang Sun
Ke Dong, Bo Li, Department of General Surgery, Hua Xi Hospital, Si Chuan University. Cheng Du 610041, Si Chuan Province,China
Yang Qin, Cheng-Zhi Li, Zhi-Lin Sun, Ze-Fang Sun, Department of Biochemistry, Basis Medical College, Si Chuan University. Cheng Du 610041, Si Chuan Province,China
Correspondence to:Ke Dong,Department of General Surgery, Hua Xi Hospital, Si Chuan University. Cheng Du 610041, Si Chuan Province,China.
Received 2002-07-01 Accepted 2002-07-30
AbstractAIM:To assess the methylation patterns in CpG islands of p15 and p16 tumor suppressor genes.
METHODS: The methylation-specific PCR ( MSP ) was used to monitor methylation patterns in the CpG islands of p15 and p16 genes in paraffin-embedded tissues from 29 cases of pancreatic cancer and 3 chronic pancreatitis, as well as 2 normal liver tissues and 12 normal blood samples. ......
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