幽门螺杆菌感染者的生存竞争优势
张卫民,赖卓胜,周殿元,项目负责人,:,Survivaladvantageinhostswith,Hpyloriinfection,Correspondenceto:,Abstract,摘要,目的,方法,结果,结论,0,引言,1,材料和方法,1.1材料,1.2方法,2,结果,2.1Hpylori-CABP对消化道常见菌的抗菌活性,2.2Hpylor
张卫民,赖卓胜, 周殿元,中国人民解放军第一军医大学南方医院全军消化病研究所 广东省广州市 510515张卫民,男, 湖北省荆州市人,满族. 1986年第四军医大学学士,1994年第一军医大学硕士,副主任医师.主要从事消化系统疾病的微生态及肿瘤应用基础研究.
项目负责人:张卫民,510515, 广东省广州市同和,中国人民解放军第一军医大学南方医院全军消化病研究所. weigert@163.com
电话:020-61641536 传真:020-61647788
收稿日期:2003-06-06 接受日期:2003-08-25
Survival advantage in hosts with Hpylori infection
Wei-MinZhang, Zou-Shen Lai, Dian-Yuan Zhou
Wei-Min Zhang, Zou-Shen Lai, Dian-Yuan Zhou. Institute for DigestiveDisease, the First Military Medical University, Guangzhou 510515,Guangdong Province, China
Correspondence to: Wei-Min Zhang. Chinese PLA Institute forDigestive Disease, the First Military Medical University, Guangzhou510515, Guangdong Province, China.
Received: 2003-06-06 Accepted:2003-08-25
AbstractAIM: To study the in vitro killing effects of cecropin-likeantibacterial peptide from H pylori Hp (2-20) on thegastrointestinal bacterial pathogens and to explore the survival advantageto the host of infection with H pylori.
METHODS: The inhibition zone assay was used to determine anti-bacterialactivity and lethal concentrations of H pylori antibacterialpeptide Hp (2-20) on the gastrointestinal bacterial pathogens. Therate of killing of E.coliK12D31 (standardstrain) by Hp (2-20) was estimated by counting viable bacteriabased on counting of colonies grown in Luria-Bertani plate. Thecytotoxicity of the Hp (2-20) peptides on human gastric epithelialcell line was measured by trypan blue exclusion test. ......
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