【摘要】 目的 观察米索前列醇联合异丙酚实行无痛人工流产术的临床效果。方法 400例实行无痛人工流产的早孕患者随机分为2组。其中A组:术前2h口服米索前列醇600μg;B组:术前不服任何药物。术中以2.0mg/s的速度单次静推异丙酚3.0mg/kg，必要时追加0.5mg/kg。观察受术者宫口松弛情况、术中出血量、麻醉效果、追加用药例数、手术时间、受术者苏醒时间、自行离床时间;观察异丙酚推药前、推药后2min及手术后的血压、心率、呼吸、血氧饱和度的变化。结果 两组间的宫口松弛、术中出血量、麻醉效果、追加药例数、手术时间、受术者苏醒时间及自行离床时间比较差异有显著性(P<0.05)。与麻醉前比较，两组推药后2min其血压、心率、呼吸、血氧饱和度差异均无显著性(P>0.05);术后B组的血压、心率、血氧饱和度下降明显，呼吸增快，差异有显著性(P<0.05);术后A组也有血压、心率、血氧饱和度下降、呼吸增快，但差异无显著性(P>0.05)。结论 米索前列醇联合异丙酚实行无痛人工流产术，可提高麻醉效果，减少异丙酚术中用量，降低异丙酚对循环、呼吸的抑制作用。

    关键词 米索前列醇 异丙酚 无痛人工流产术

    The clinical observation on misoprostol and propofol in painless induced abortion

    Liu Peiyu，Zhou Yumei，Zhang Lihong

    Maternity and Health Institute of Dongguan，Guangdong523002.

    【Abstract】 Objective To observe the effect of combined application of misoprostol and propofol in painless induced abortion. Methods Four hundred early pregnancy patients receiving painless abortion were classified randomly into two groups. Group A: received 600μg misoprostol before operation; Group B: without misoprostol. Both were given propofol 3mg/kg(the single dosage)to induce anesthesia. The speed of injection was kept 2.0mg/s.0.5mg/kg propofol was given accorinding to the situation during operation. The following parameters were observed: the loosening of vervix ......