【摘要】 目的 评价曲美他嗪(TMZ)与传统药物相结合对2型糖尿病并稳定型心绞痛患者抗心绞痛的疗效。方法 67例2型糖尿病且至少有3个月以上的稳定的、可由劳累诱发的心绞痛病史的患者入选试验，随机分成两组，一组给予TMZ20mg，每天3次联合使用β受体阻滞剂，钙通道阻滞剂和长效硝酸酯类治疗12周，另一组单用β受体阻滞剂、钙通道阻滞剂和长效硝酸酯类治疗12周，对疗效进行统计学分析。结果 与对照组比较，TMZ组患者心绞痛发作次数及硝酸甘油消耗量明显降低，而至心绞痛发作的时间、EF%明显增加，两组的空腹血糖、餐后2h血糖、空腹胰岛素、HbAlc、血压、血脂差异无显著性。结论 TMZ20mg，每天3次与其他药物联用对2型糖尿病伴稳定性劳力型心绞痛患者有效且安全。

    Hua Jialin，Xu Lan

    The First People’s Hospital of Wuxi，Wuxi，Jiangsu214002.

    【Abstract】 Objective To assess the anti-anginal efficacy of trimetazidine(TMZ)in combination with conˉventional treatment in type2diabetic patients with stable angina pectoris.Methods Sixty-seven type2diabetic paˉtients with stable angina pectoris were included，then divided into two groups:one group was given TMZ20mg tid comˉbined with three traditional drugs includingβ-blockers ......