基金项目:佛山市科技局重大科技攻关资助项目(编号:0308001)

    【摘要】 目的 求证佛山地区首批SARS患者的病原体。方法 以SARS冠状病毒全病毒裂解液作抗原，利用ELISA技术检测佛山地区首批出现急性呼吸窘迫综合征并具有明显传染特征的SARS康复患者和患者居住地“健康者”血清中抗SARS冠状病毒抗体。结果 4组有流行病学关系的19例SARS患者血清中抗SARS冠状病毒抗体全部阳性，而400例患者居住地的“健康者”血清中抗SARS冠状病毒抗体则全部阴性。结论 佛山地区首批SARS病例血清学病原体调查结果完全支持SARS的病原体为SARS冠状病毒;抗SARS抗体IgG在SARS康复者血清中至少可存在6个

    月。

    Investigation of serum antibody against SARS coronavirus in the earliest patients with SARS in China supports SARS coronavirus as the pathogen

    Yang Guang，Tan Jiaju，Si Jianhua，et al.

    The First People’s Hospital of Foshan，Foshan528000.

    【Abstract】 Objective To identify the pathogen in the earliest patients with SARS in China.Methods Using the lysate of whole SARS coronavirus as antigen，and ELISA as technique，to investigate serum antibody against SARS coronavirus in the earliest patients with SARS in China who were characterized with infectivity and acute respiratory disˉtress syndrome(ARDS)and in the healthy persons in this region.Results Serum antibody against SARS coronavirus in the4groups of19cases was all positive;whereas that in400healthy control cases living in the same region was all negaˉtive.Conclusion Investigation of serum antibody against SARS coronavirus in the earliest patients with SARS in China supports SARS coronavirus as the pathogen ......